Abstract
Reactions of 2-dicyanomethylidene-3-ethoxymethylidene-2,3-dihydroindole with various amines afforded enamino dinitriles and the corresponding pyrido[4,3-b]indoles (γ-carbolines). 3-Amino-4-cyano-5H-pyrido[4,3-b]indole reacted with cyclohexanone to give pentacyclic 13-amino-2,3,4,12-tetrahydro-1H-benzo[b]indolo[2,3-f]-1,8-naphthyridine. Alkylation of pyrido[4,3-b]indoles with various alkylating agents was studied.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2361–2368, November, 2008.
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Smirnova, O.B., Golovko, T.V., Alekseeva, L.M. et al. A new approach to the synthesis of pyrido[4,3-b]indole derivatives (γ-carbolines) via cyclization of enamino dinitriles. Russ Chem Bull 57, 2410–2417 (2008). https://doi.org/10.1007/s11172-008-0344-9
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DOI: https://doi.org/10.1007/s11172-008-0344-9