Abstract
Main pathways in reactions of lactim ethers with cyanoacetic acid hydrazide depend on the ring size of the starting lactim ether. Five-membered O-methylbutyrolactim produces pre-dominantly 3-amino-4-(pyrrolidin-2-ylidene)-4,5-dihydropyrazol-5-one, whereas condensation of six-and seven-membered lactim ethers (O-methylvalero-and O-methylcaprolactim, respectively) affords the corresponding polymethylenetriazoles as the major products.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 1577–1582, September, 2006.
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Nilov, D.B., Granik, V.G. Study of reactions of lactim ethers with cyanoacetohydrazide. Russ Chem Bull 55, 1636–1641 (2006). https://doi.org/10.1007/s11172-006-0466-x
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DOI: https://doi.org/10.1007/s11172-006-0466-x