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New phosphoramidite derivatives for the preparation of oligonucleotides containing a hydrazide group in any specified position of the oligonucleotide chain

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Russian Chemical Bulletin Aims and scope

Abstract

A new versatile method for the preparation of oligonucleotides containing hydrazide groups in any position of the oligonucleotide chain by standard phosphoramidite automated oligonucleotide synthesis is proposed. The method is based on the use of a series of new modified components for oligonucleotide synthesis. An original protecting group for the hydrazide group is proposed. The presence of the hydrazide group in the obtained oligonucleotides and its high reactivity were demonstrated by the reaction with 4-methoxybenzaldehyde in solution.

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Authors and Affiliations

  1. Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie gory, 119992, Moscow, Russian Federation

    S. I. Antsypovich & T. S. Oretskaya

  2. Department of Chemistry, Ruhr University, 150 Universitätsstrasse, Bochum, Germany

    S. I. Antsypovich & G. von Kiedrowski

Authors
  1. S. I. Antsypovich
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  2. T. S. Oretskaya
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  3. G. von Kiedrowski
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2585–2595, November, 2005.

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Antsypovich, S.I., Oretskaya, T.S. & von Kiedrowski, G. New phosphoramidite derivatives for the preparation of oligonucleotides containing a hydrazide group in any specified position of the oligonucleotide chain. Russ Chem Bull 54, 2671–2681 (2005). https://doi.org/10.1007/s11172-006-0175-5

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  • DOI: https://doi.org/10.1007/s11172-006-0175-5

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