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Single-step synthesis of substituted 7-aminopyrano[2,3-d]pyrimidines

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Abstract

A single-step method for the synthesis of substituted 7-aminopyrano[2,3-d]pyrimidines was developed. The method involves a three-component reaction of barbituric acid or 4,6-dihydroxypyrimidine with aromatic aldehydes and malononitrile in DMF in the presence of N-methylmorpholine as a catalyst.

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Authors and Affiliations

  1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation

    A. A. Shestopalov, L. A. Rodinovskaya, A. M. Shestopalov & V. P. Litvinov

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  1. A. A. Shestopalov
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  2. L. A. Rodinovskaya
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  3. A. M. Shestopalov
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  4. V. P. Litvinov
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 2242–2244, October, 2004.

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Shestopalov, A.A., Rodinovskaya, L.A., Shestopalov, A.M. et al. Single-step synthesis of substituted 7-aminopyrano[2,3-d]pyrimidines. Russ Chem Bull 53, 2342–2344 (2004). https://doi.org/10.1007/s11172-005-0128-4

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  • DOI: https://doi.org/10.1007/s11172-005-0128-4

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