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Synthesis of 3-aminoisoxazolmethylnaphthols via one-pot three-component reaction under solvent-free conditions

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Abstract

A one-pot three-component condensation reaction of 3-amino-5-methylisoxazole, aryl aldehyde and 2-naphthol to afford the corresponding 3-amino isoxazolmethylnaphthols in good to excellent yields. The remarkable features of this new procedure are high conversions, clean reaction condition, short reaction time, nonhazardous and environmentally friendly reaction condition, inexpensive and easily commercially availability of the catalyst and simple work-up procedures.

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Acknowledgements

We gratefully acknowledge financial support from the Research Council of the University of Sistan and Baluchestan.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran

    Mohyeddin Safarzaei, Malek Taher Maghsoodlou, Ebrahim Mollashahi & Nourallah Hazeri

  2. Faculty of Sciences, Velayat University, Iranshahr, Iran

    Mojtaba Lashkari

Authors
  1. Mohyeddin Safarzaei
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  2. Malek Taher Maghsoodlou
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  3. Ebrahim Mollashahi
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  4. Nourallah Hazeri
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  5. Mojtaba Lashkari
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Correspondence to Malek Taher Maghsoodlou.

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Safarzaei, M., Maghsoodlou, M.T., Mollashahi, E. et al. Synthesis of 3-aminoisoxazolmethylnaphthols via one-pot three-component reaction under solvent-free conditions. Res Chem Intermed 44, 7449–7458 (2018). https://doi.org/10.1007/s11164-018-3566-y

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