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Practical synthesis of 2-(4-benzyl-piperazin-1-ylmethyl)-5, 6-dimethoxy-3-methyl-[1, 4]benzoquinone hydrochloride

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Abstract

The title compound was readily prepared from 2, 3, 4, 5-tetramethoxytoluene via the Blanc reaction, oxidation, and alkylation. The described method provides a good yield of the heterocyclic substitute at the C-5 position of the Coenzyme Q homologue and is suitable for the synthesis of other homologues.

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Acknowledgement

This study was supported by the National Natural Science Foundation for Young Scientists of China, the China Scholarship Council, the College students practice innovation training program of Yancheng Teachers University, and the Natural Science Foundation of Yancheng Teachers University.

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    Authors and Affiliations

    1. School of Pharmacy, Yancheng Teachers University, Yancheng, 224007, Jiangsu Province, People’s Republic of China

      Qiong Qiu, Wen-Ling Wang & Jin Wang

    2. Library of Yancheng Teachers University, Yancheng, 224007, Jiangsu Province, People’s Republic of China

      Xiao Hu

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    1. Xiao Hu
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    2. Qiong Qiu
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    3. Wen-Ling Wang
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    4. Jin Wang
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    Corresponding authors

    Correspondence to Wen-Ling Wang or Jin Wang.

    Additional information

    Xiao Hu and Qiong Qiu have contributed equally to this work.

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    Hu, X., Qiu, Q., Wang, WL. et al. Practical synthesis of 2-(4-benzyl-piperazin-1-ylmethyl)-5, 6-dimethoxy-3-methyl-[1, 4]benzoquinone hydrochloride. Res Chem Intermed 43, 57–61 (2017). https://doi.org/10.1007/s11164-016-2605-9

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