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An eco-compatible synthesis of novel spiro[acenaphthylene-1,2′[1,3]-thiazolidine]-2,4′(1H)-diones using thiamine hydrochloride as efficient catalyst in aqueous medium

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Abstract

A water mediated and thiamine hydrochloride catalysed eco-compatible efficient method was developed for the synthesis of spiro[acenaphthylene-1,2′[1,3]-thiazolidine]-2,4′(1H)-diones via multi-component reaction of acenaphthylene-1,2-dione, substituted anilines, and α-mercaptocarboxylic acid at 80 °C temperature. This transformation involves the formation of two C–N bonds and one C–S bond leading to the creation of a five-member ring in a one-pot operation. Easy availability and recovery of the catalyst, no toxic/organic solvents, and high yield of product make the protocol attractive, sustainable, and economic.

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Acknowledgments

R.S. thanks DST, New Delhi for start-up Grant (YSS/2015/000972). We are thankful to the Central Drug Research Institute (CDRI), Lucknow, and MNIT, Jaipur for the spectral analyses and elemental analyses.

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  1. Department of Chemistry, School of Basic Sciences, Jaipur National University, Jaipur, Rajasthan, India

    Ruby Singh & Shakeel Ahmad Ganaie

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  1. Ruby Singh
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Correspondence to Ruby Singh.

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Singh, R., Ganaie, S.A. An eco-compatible synthesis of novel spiro[acenaphthylene-1,2′[1,3]-thiazolidine]-2,4′(1H)-diones using thiamine hydrochloride as efficient catalyst in aqueous medium. Res Chem Intermed 43, 45–55 (2017). https://doi.org/10.1007/s11164-016-2604-x

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