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A facile synthesis of novel pyrrolo[3,4-b]quinolin-1-one derivatives

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Abstract

A simple and concise construction of a series of new quinoline-based isoindolin-l-ones, namely N-substituted-2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-1-ones, wherein the benzene moiety of isoindolin-l-one is replaced by a quinoline ring has been achieved via a two-step procedure, involving the one-step synthesis of ethyl 2-chloromethyl-quinoline-3-carboxylate followed by its one-pot reaction with various amines in a refluxing EtOH–AcOH (v/v, 10:1) solvent system. These newly synthesized compounds could be good candidates for the development of lead compounds for use in medicinal chemistry.

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Acknowledgments

The authors would like to thank the Scientific Research Foundation of the National Natural Science Foundation of China (Grant Nos. 21402011 and 21476028) for financial support.

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Authors and Affiliations

  1. Institute of Superfine Chemicals, Bohai University, Jinzhou, 121000, China

    Kai Li, Xinbo Fu, Yanan Zhao, Wentao Gao & Yang Li

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  1. Kai Li
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  2. Xinbo Fu
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  3. Yanan Zhao
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  4. Wentao Gao
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  5. Yang Li
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Correspondence to Yang Li.

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Li, K., Fu, X., Zhao, Y. et al. A facile synthesis of novel pyrrolo[3,4-b]quinolin-1-one derivatives. Res Chem Intermed 42, 4273–4287 (2016). https://doi.org/10.1007/s11164-015-2273-1

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