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Pyridine-based, microwave-assisted one-pot synthetic protocol for the synthesis of ethyl 3-substituted-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates

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Abstract

Pyridine has been used for one-pot, two-component synthesis of ethyl 3-substituted-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives in moderate to good yields by condensing N-substituted thioureas with diethyl ethoxymalonate under microwave irradiation.

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Acknowledgments

The authors gratefully acknowledge the financial support from the Department of Biotechnology (BT/IN/Canada/22/AM/2009), New Delhi, India as a part of the ISTP Canada-DBT Collaborative R&D Program. Authors are also thankful to the Birla Institute of Technology & Science (BITS), Pilani, India, and SAIF, Panjab University, Chandigarh, India, for providing the infrastructure facilities and analytical facilities, respectively. The authors are grateful to Dr. L.P. Kotra (University Health Network, Toronto, Canada), Dr. Sai Kumar Chakka (Encycle Therapeutics, Toronto-Canada) and Dr. Asif Mohmmed (ICGEB, Delhi, India) for their valuable suggestions.

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  1. Department of Pharmacy, FD-III, Birla Institute of Technology and Science, Pilani, Pilani, Rajasthan, 333031, India

    Sourabh Mundra & Radhakrishnan Mahesh

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  1. Sourabh Mundra
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  2. Radhakrishnan Mahesh
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Correspondence to Sourabh Mundra.

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Mundra, S., Mahesh, R. Pyridine-based, microwave-assisted one-pot synthetic protocol for the synthesis of ethyl 3-substituted-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates. Res Chem Intermed 42, 4207–4219 (2016). https://doi.org/10.1007/s11164-015-2270-4

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  • DOI: https://doi.org/10.1007/s11164-015-2270-4

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