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Facile microwave-assisted synthesis of 1H-pyrazino[1,2-a]quinoxaline-1,5(6H)-dione derivatives via a nucleophilic substitution reaction

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Abstract

A series of compounds containing the 1H-pyrazino[1,2-a]quinoxaline-1,5(6H)-dione scaffold have been synthesized using a one-pot procedure under microwave irradiation. This new strategy allowed for the facile synthesis of target compounds in good yields and could be readily applied to the construction of diverse libraries of compounds for high throughput screening in medicinal chemistry.

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Authors and Affiliations

  1. Key Laboratory of the Ministry of Education for Advanced Catalysis Materials; Department of Chemistry and Life Science, Zhejiang Normal University, Jinhua, 321004, China

    Xiaoyan Zhang

  2. Drug Discovery Center of Innovation, Chongqing University of Arts and Sciences, Chongqing, 402160, China

    Hailei Cui, Zhigang Xu & Zhongzhu Chen

  3. Key Laboratory for Asymmetric Synthesis and Chiral Technology of Sichuan Province; Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China

    Guiting Song & Jin Zhu

  4. University of Chinese Academy of Sciences, Beijing, 100049, China

    Guiting Song

Authors
  1. Xiaoyan Zhang
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  2. Guiting Song
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  3. Hailei Cui
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  4. Zhigang Xu
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  5. Jin Zhu
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  6. Zhongzhu Chen
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Correspondence to Jin Zhu or Zhongzhu Chen.

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Zhang, X., Song, G., Cui, H. et al. Facile microwave-assisted synthesis of 1H-pyrazino[1,2-a]quinoxaline-1,5(6H)-dione derivatives via a nucleophilic substitution reaction. Sci. China Chem. 58, 1239–1242 (2015). https://doi.org/10.1007/s11426-015-5431-9

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  • DOI: https://doi.org/10.1007/s11426-015-5431-9

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