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Synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by succinimide-N-sulfonic acid as a mild and efficient catalyst

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Abstract

A simple, green and environmentally benign procedure was developed for the synthesis of 2,3-dihydro-2-phenylquinazolin-4(1H)-ones using catalytic amounts of succinimide-N-sulfonic acid via the cyclocondensation of 2-aminobenzamide with an aldehyde. The present methodology offers several advantages such as high yields, simple procedure, low cost, short reaction times, mild reaction conditions, and use of a reusable catalyst.

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Acknowledgment

S.S. Mansoor expresses his gratitude to the management of C. Abdul Hakeem College, Melvisharam, India, for the facilities and support.

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Authors and Affiliations

  1. Faculty of Sciences, Islamic Azad University, Najafabad Branch, P.O. Box 517, Najafabad, Esfahan, Iran

    Majid Ghashang

  2. Bioactive Organic Molecule Synthetic Unit, Research Department of Chemistry, C. Abdul Hakeem College, Melvisharam, 632 509, Tamil Nadu, India

    Syed Sheik Mansoor & Krishnamoorthy Aswin

Authors
  1. Majid Ghashang
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  2. Syed Sheik Mansoor
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  3. Krishnamoorthy Aswin
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Correspondence to Syed Sheik Mansoor.

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Ghashang, M., Mansoor, S.S. & Aswin, K. Synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by succinimide-N-sulfonic acid as a mild and efficient catalyst. Res Chem Intermed 41, 3447–3460 (2015). https://doi.org/10.1007/s11164-013-1447-y

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  • DOI: https://doi.org/10.1007/s11164-013-1447-y

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