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Efficient and extremely facile one-pot four-component synthesis of mono and bis-N-aryl/alkyl-3-aminodihydropyrrol-2-one-4-carboxylates catalyzed by p-TsOH·H2O

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An Erratum to this article was published on 21 September 2013

Abstract

An efficient and straightforward procedure has been developed for synthesis of mono and bis-N-aryl/alkyl-3-aminodihydropyrrol-2-one-4-carboxylates via one-pot four-component domino reaction of amines, dialkyl acetylenedicarboxylates, and formaldehyde, in the presence of p-TsOH·H2O (15 mol%), in MeOH at ambient temperature. The salient advantages of this method are mild reaction conditions, high to excellent yields, shorter reaction times, atom economy, easy operation, and no column chromatographic separation.

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Acknowledgments

We are grateful to the Research Council of University of Sistan and Baluchestan for financial support of this work.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, Islamic Azad University, Najafabad Branch, P.O. Box 517, Najafabad, Esfahan, Iran

    Seyed Sajad Sajadikhah

  2. Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran

    Malek Taher Maghsoodlou & Nourallah Hazeri

Authors
  1. Seyed Sajad Sajadikhah
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  2. Malek Taher Maghsoodlou
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  3. Nourallah Hazeri
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Correspondence to Seyed Sajad Sajadikhah.

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Sajadikhah, S.S., Maghsoodlou, M.T. & Hazeri, N. Efficient and extremely facile one-pot four-component synthesis of mono and bis-N-aryl/alkyl-3-aminodihydropyrrol-2-one-4-carboxylates catalyzed by p-TsOH·H2O. Res Chem Intermed 41, 2503–2511 (2015). https://doi.org/10.1007/s11164-013-1364-0

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