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Synthesis and characterization of new N-phenylmaleimide thioglycosides


Thioglycosides derivatives of N-phenylmaleimide have been prepared by the reaction of derivatives of 1-thio-d-glucopyranose, d-galactopyranose, d-lactose, and d-maltose with 3,4-dichloro-N-phenylmaleimide. The reaction of 3,4-dichloro-N-phenyl maleimide with sugar thiols (protected or unprotected) took place by displacement of both chlorine atoms by sulfide nucleophile giving the corresponding bis-thioglycoside products.

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We wish to thank the Hashemite University for financial support.

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Correspondence to Bader A. Salameh.

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Salameh, B.A., Abu-Safieh, K.A., Al-Kaabenah, S.R.A. et al. Synthesis and characterization of new N-phenylmaleimide thioglycosides. Res Chem Intermed 40, 3001–3009 (2014).

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  • Thioglycosides
  • Sugar thiols
  • N-phenylmaleimide