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Synthesis and characterization of new phenyl esters derived from 16-dehydropregnenolone acetate (16-DPA)

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Abstract

A series of new phenyl esters based on a 5,16-pregnadiene-20-one skeleton, namely 3β-benzoyloxy-5,16-pregnadiene-20-ones, which may be good inhibitors of 17α-hydroxylase and 5α-reductase enzyme or useful intermediates for producing steroidal drugs, were synthesized starting from diosgenin. The structures of the steroids were characterized by 1H nuclear magnetic resonance (NMR), 13C NMR, infrared (IR), and mass spectra.

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Acknowledgments

The authors acknowledge the financial support of the project by Shanghai Natural Science Foundation (No. 06ZR14001).

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Authors and Affiliations

  1. Key Laboratory of Science and Technology of Eco-Textile, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, 2999 North Renmin Road, Shanghai, 201620, People’s Republic of China

    Hongqi Li, Jueshu Fang, Juan Li, Yulong Wang, Xiujuan Tian & Yuanhui Xiang

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  1. Hongqi Li
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  2. Jueshu Fang
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  3. Juan Li
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  4. Yulong Wang
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  5. Xiujuan Tian
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  6. Yuanhui Xiang
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Correspondence to Hongqi Li.

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Li, H., Fang, J., Li, J. et al. Synthesis and characterization of new phenyl esters derived from 16-dehydropregnenolone acetate (16-DPA). Res Chem Intermed 39, 3887–3893 (2013). https://doi.org/10.1007/s11164-012-0890-5

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  • DOI: https://doi.org/10.1007/s11164-012-0890-5

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