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Synthesis of some new pyrimidine derivatives and evaluation of their anticancer and antibacterial activities

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Abstract

Starting from the reaction of ethyl cyanoacetate with thiourea and the appropriate aldehydes, a series of new pyrimidine derivatives were prepared. Ten selected pyrimidine derivatives were subjected to a screening system for the investigation of their antitumor potency against liver (HEPG2) cell line. The antitumor activity results indicated that most of the selected pyrimidine derivatives showed moderate growth inhibition activity against the tested cell line, but with varying intensities in comparison to the known anticancer drugs: 5-fluorouracil and doxorubicin. Some of the synthesized compounds were also tested for their antimicrobial activity against bacteria as well as fungal isolates.

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Authors and Affiliations

  1. Therapeutical Chemistry Department, National Research Center, Dokki, Cairo, Egypt

    Omar A. Fathalla, Neama A. Mohamed, Walaa S. El-Serwy & Abdel-mohsen M. Soliman

  2. Chemistry of Pesticides Department, National Research Center, Dokki, Cairo, Egypt

    Hala F. AbdelHamid

  3. Microbiology and Immunology Department, National Research Center, Dokki, Cairo, Egypt

    Sherein I. Abd El-Moez

Authors
  1. Omar A. Fathalla
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  2. Neama A. Mohamed
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  3. Walaa S. El-Serwy
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  4. Hala F. AbdelHamid
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  5. Sherein I. Abd El-Moez
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  6. Abdel-mohsen M. Soliman
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Correspondence to Abdel-mohsen M. Soliman.

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Fathalla, O.A., Mohamed, N.A., El-Serwy, W.S. et al. Synthesis of some new pyrimidine derivatives and evaluation of their anticancer and antibacterial activities. Res Chem Intermed 39, 821–841 (2013). https://doi.org/10.1007/s11164-012-0597-7

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  • DOI: https://doi.org/10.1007/s11164-012-0597-7

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