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Synthesis and Anticancer Activity of New Substituted Piperidinones Linked to Pyrimidine, Thiazole, and Triazole Glycoside Derivatives

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Abstract

New piperidinone incorporating pyrimidine, triazine, diazipine, oxatriazine, and thiazole derivatives have been synthesized starting with tetramethylpipridin-4-one. Structures of the newly synthesized compounds are characterized on the basis of spectroscopic and analytical data. The anticancer activity of the prepared compounds has been studied in vitro against HCT-116 and MCF-7 human cancer cells using the MTT assay. A number of compounds demonstrates potent activity towards both cell lines with IC50 values comparable with doxorubicin.

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Authors and Affiliations

  1. Photochemistry Department, National Research Centre, Cairo, Egypt

    M. N. M. Yousif, N. M. Yousif & W. A. El-Sayed

  2. Faculty of Specific Education, Ain Shams University, Cairo, Egypt

    I. F. Nassar

  3. Tanning Materials and Leather Technology Department, National Research Centre, El-Behouth St, Dokki, Cairo, Egypt

    H. M. Awad

  4. Chemistry Department, Faculty of Science, Qassim University, Buraydah, Saudi Arabia

    W. A. El-Sayed

Authors
  1. M. N. M. Yousif
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  2. I. F. Nassar
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  3. N. M. Yousif
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  4. H. M. Awad
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  5. W. A. El-Sayed
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Correspondence to M. N. M. Yousif or W. A. El-Sayed.

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Yousif, M.N.M., Nassar, I.F., Yousif, N.M. et al. Synthesis and Anticancer Activity of New Substituted Piperidinones Linked to Pyrimidine, Thiazole, and Triazole Glycoside Derivatives. Russ J Gen Chem 89, 1673–1682 (2019). https://doi.org/10.1134/S1070363219080218

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  • DOI: https://doi.org/10.1134/S1070363219080218

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