Abstract
The Rab family of proteins is involved in organelle regulation, trafficking, signal transduction, mitosis, phagocytosis, growth differentiation, cytoskeleton protein depolymerization and other cellular functions and abnormal expression has been associated with many pathologies, including cancer. Previous work has focused on Rab function in higher animals but fish, crustaceans and other aquatic animals also express the Rab proteins. The current review summarizes research progress on Rab proteins, focusing on immune defense against pathogens in aquatic animals. Some differences in Rab protein function between aquatic and higher animals were found and greater involvement in the fish and crustacean immune system than that of higher animals. Novel insights into Rab protein in aquatic animals are offered with implications for the development of aquaculture strategies.
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The authors acknowledge the help and support of other members of the Aquatic Animal Immunization and Disease Control Team of Henan Normal University during the preparation of the present manuscript.
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This research was supported by the National Natural Science Foundation of China (No. 32202968), Henan Province young backbone teacher training program(2023GGJS038), Key Project in Science and Technology Research in Henan Province (No. 212102110107), and Natural Science Foundation of Henan Province (No. 212300410177).
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LZ: data curation; validation; visualization; writing—original draft; writing-review and editing. YG: visualization, resources, and software. YK: resources. XW: writing—review and editing. HL: investigation and methodology. LH: investigation and methodology. XK: writing—review; supervision; validation.
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Zhu, L., Gu, Y., Kong, Y. et al. Rab proteins in fish and crustaceans: an overview. Rev Fish Biol Fisheries (2024). https://doi.org/10.1007/s11160-024-09859-x
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DOI: https://doi.org/10.1007/s11160-024-09859-x