Summary
In recombinant fermentations the plasmid loss probability per generation depends on the specific growth rate, which is related linearly to the dilution rate. A model with this feature and incomplete mixing has been studied analytically for stationary state behavior. While the kinetic parameters place upper limits on the dilution rate for a feasible stationary state in a well-mixed bioreactor, the feasible and nonfeasible regions for an incompletely mixed reactor are separated by either a straight line or a plane, whose position is determined by the mixing conditions.</o:p>
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Pratap R. Patnaik Feasibility and uniqueness of stationary states of nonideal recombinant fermentations<span style='mso-spacerun:yes'> . React Kinet Catal Lett 87, 11–18 (2005). https://doi.org/10.1007/s11144-006-0003-9
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DOI: https://doi.org/10.1007/s11144-006-0003-9