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Monitoring of Radionuclide Impurities in 166Ho-Albumin Microspheres Prepared by Neutron Activation with Thermal Neutrons

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Abstract

Analysis of radionuclide impurities in 166Ho-albumin microspheres prepared by activation with thermal neutrons of 165Ho preliminarily incorporated in the particle matrix was performed. The content of impurities in the final product was determined by γ-ray spectroscopy. With 166Ho-albumin microspheres as example, an algorithm was developed for evaluation of the radiochemical purity of the preparation. It was found that the radiochemical purity of the preparation, which is primarily determined by impurities of rare-earth elements, can be estimated from the content of 152mEu.

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REFERENCES

  1. Hafeli, U.O., Casillas, S., Dietz, D.W., et al., Int. J. Radiat. Oncol. Biol. Phys., 1999, vol. 44, pp. 189–199.

    CAS  PubMed  Google Scholar 

  2. Mumper, R.J., Ryo, U.Y., and Jay, M., J. Nucl. Med., 1991, vol. 32, pp. 2139–2143.

    CAS  PubMed  Google Scholar 

  3. Nijsen, J.F.W., Zonnenberg, B.A., Woittiez, J.R.W., et al., Eur. J. Nucl. Med., 1999, vol. 26, pp. 699–704.

    CAS  PubMed  Google Scholar 

  4. Hafeli, U.O., Sweeney, S.M., Beresford, B.A., et al., J. Biomed. Res. 1994, vol. 28, pp. 901–908.

    CAS  Google Scholar 

  5. Turner, J.H., Claringbold, P.G., Klemp, P.F.B., et al., Nucl. Med. Commun., 1994, vol. 15, pp. 545–553.

    CAS  PubMed  Google Scholar 

  6. Schubiger, P.A., Beer, H.F., and Geiger, L., Nucl. Med. Biol. 1991, vol. 18, pp. 305–311.

    CAS  Google Scholar 

  7. Wang, S.J., Lin, W.Y., Chen, M.N., et al., J. Nucl. Med., 1998, vol. 39, pp. 1752–1757.

    CAS  PubMed  Google Scholar 

  8. Burton, M.A., Gray, B.N., Klemp, P.F., et al., Eur. J. Cancer Clin. Oncol., 1989, vol. 25, pp. 1487–1991.

    CAS  PubMed  Google Scholar 

  9. Wunderlich, G., Pinkert, J., Andreeff, M., et al., Appl. Radiat. Isot., 2000, vol. 52, pp. 63–68.

    CAS  PubMed  Google Scholar 

  10. Watanabe, N., Oriuchi, N., Endo, K., et al., Nucl. Med. Biol., 1999, vol. 26, pp. 847–851.

    CAS  PubMed  Google Scholar 

  11. Ehrhardt, G.J. and Day, D.E., Nucl. Med. Biol., 1987, vol. 14, pp. 233–242.

    CAS  Google Scholar 

  12. Conzone, S.D., Hafeli, U.O., Day, D.E., and Ehrhardt, G.J., J. Biomed. Mater. Res., 1998, vol. 42, pp. 617–625.

    CAS  PubMed  Google Scholar 

  13. Kawashita, M., Miyaji, F., Kokubo, T., et al., J. Non-Cryst. Solids, 1999, vol. 255, pp. 140–148.

    CAS  Google Scholar 

  14. Mumper, J. and Jay, M., Pharm. Res., 1992, vol. 9, no.1, pp. 149–154.

    CAS  PubMed  Google Scholar 

  15. Mumper, J., Mills, B.J., Ryo, U.Y., and Jay, V., J. Nucl. Med., 1992, vol. 33, no.3, pp. 398–402.

    CAS  PubMed  Google Scholar 

  16. Currie, L.A., Anal. Chem., 1968, vol. 40, p. 586.

    Google Scholar 

  17. Nalimov, V.V., Primenenie matematicheskoi statistiki pri analize veshchestva (Mathematical Statistics in the Analysis of Substances), Moscow: Fizmatgiz, 1960.

    Google Scholar 

  18. Smakhtin, L.A., J. Radioanal. Nucl. Chem., 1986, vol. 99, no.1, pp. 171–180.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Medical Radiological Scientific Center, State Institution, Russian Academy of Medical Sciences, Obninsk, Kaluga oblast, Russia

    V. M. Petriev & V. G. Skvortsov

  2. Branch of the Karpov Research Physicochemical Institute, Federal State Unitary Enterprise, Obninsk, Kaluga oblast, Russia

    L. A. Smakhtin & I. N. Shutova

Authors
  1. V. M. Petriev
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  2. V. G. Skvortsov
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  3. L. A. Smakhtin
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  4. I. N. Shutova
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__________

Translated from Radiokhimiya, Vol. 47, No. 3, 2005, pp. 278–280.

Original Russian Text Copyright © 2005 by Petriev, Skvortsov, Smakhtin, Shutova.

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Petriev, V.M., Skvortsov, V.G., Smakhtin, L.A. et al. Monitoring of Radionuclide Impurities in 166Ho-Albumin Microspheres Prepared by Neutron Activation with Thermal Neutrons. Radiochemistry 47, 305–307 (2005). https://doi.org/10.1007/s11137-005-0093-7

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  • DOI: https://doi.org/10.1007/s11137-005-0093-7

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