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Synthesis and Stability of New Nitrophenol Complexes of 99mTc as Possible Hypoxia Imaging Radiopharmaceuticals

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Abstract

Seven new nitrophenol derivatives were synthesized; their 99mTc complexes (N2OS chelates), which are possible hypoxia tumor imaging agents, were prepared by the reaction with [99mTc]NaTcO4 in the presence of SnCl2 at pH 10. The in vitro biostabilty of the complexes was evaluated. The purity and stability (in human and rat serum) of the complexes were evaluated by chromatographic methods (TLC, HPLC). The most stable (for more than 6 h) is the complex of 99mTc with 3-[3′-N-(2″-hydroxy-5″-nitrobenzylamino)-2′-hydroxypropyl]-1-methylthiourea.

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Authors and Affiliations

  1. Cyclotron/Nuclear Medicine Department, Nuclear Research Center for Agriculture and Medicine (NRCAM), Karaj, Iran

    A. R. Jalilian & M. Binehshmarvasti

  2. Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada

    P. Kumar & L. I. Wiebe

Authors
  1. A. R. Jalilian
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  2. M. Binehshmarvasti
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  3. P. Kumar
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  4. L. I. Wiebe
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From Radiokhimiya, Vol. 47, No. 2, 2005, pp. 185–188.

Original English Text Copyright © 2005 by Jalilian, Binehshmarvasti, Kumar, Wiebe.

This article was submitted by the authors in English.

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Jalilian, A.R., Binehshmarvasti, M., Kumar, P. et al. Synthesis and Stability of New Nitrophenol Complexes of 99mTc as Possible Hypoxia Imaging Radiopharmaceuticals. Radiochemistry 47, 204–208 (2005). https://doi.org/10.1007/s11137-005-0075-9

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  • DOI: https://doi.org/10.1007/s11137-005-0075-9

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