Skip to main content
SpringerLink
Log in

2 + 1 Chelating Systems for Binding Organometallic Fragment Tc(CO) +3

  • Published:
Radiochemistry Aims and scope

Abstract

Complexation of 99, 99mTc(CO) +3 organometallic fragment with 2 + 1 chelating systems was studied. HPLC analysis showed that the dithiocarbamate complexes of 99mTc are stronger than their xanthate, acetylacetonate, and γ-methoxycarbonylmethylacetylacetonate analogs. To block the third vacancy in the technetium coordination sphere, we studied thiols, thioethers, primary and secondary amines, hydroxyl ion, imidazole, phosphines, and isocyanides. As determined by 99mTc NMR spectroscopy, the mixed-ligand complexes Tc(CO)3(DTC)L (DTC is dithiocarbamate and L is isocyanide, imidazole, and phosphine) are the most stable to the histidine challenge reaction. HPLC analysis showed that, among these 2 + 1 systems, only the DTC-isonitrile system forms a single complex with 99mTc(CO) +3 . The minimal dithiocarbamate-isocyanide concentration providing complete binding of 99mTc(CO) +3 is 10−4 M.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Schibli, R., Schubiger, A.P., Eur. J. Nucl. Med. 2002. vol. 29, no.11, pp. 1529–1542.

    Article  CAS  Google Scholar 

  2. Alberto R., Schibli, R., Waibel, R., et al., Coord. Chem. Rev., 1999, vol. 190–192, pp. 901–919.

    Article  Google Scholar 

  3. Pietzsch, H.-J., Gupta, A., Drews, A., et al., Bioconjugate Chem., 2000, vol. 11, pp. 414–424.

    Article  CAS  Google Scholar 

  4. Schibli, R., Katti, K.V., Higginbotham, C., et al., Nucl. Med. Biol., 1999, vol. 26, pp. 711–716.

    Article  CAS  PubMed  Google Scholar 

  5. Byr’ko, V.M., Ditiokarbamaty (Dithiocarbamates), Moscow: Nauka, 1984.

    Google Scholar 

  6. Grakham, J.A., J. Am. Chem. Soc., 1908, vol. 30, pp. 314–316.

    Google Scholar 

  7. Alberto, R., Ortner, K., Wheatley, N.N., et al., J. Am. Chem. Soc., 2001, vol. 123, pp. 3135–3136.

    CAS  PubMed  Google Scholar 

  8. Miroslavov, A.E., Gorshkov, N.I., Lumpov, A.A., and Suglobov, D.N., Radiokhimiya, 2000, vol. 42, no.3, pp. 213–218.

    Google Scholar 

  9. Barric, J.C., Ferdette, M., and Locn, C.J.L., Can. J. Chem., 1973, vol. 51, no.2, pp. 317–324.

    Google Scholar 

  10. Doyle, G., Inorg. Chem., 1975, vol. 14, no.8, pp. 2008–2009.

    CAS  Google Scholar 

  11. Gorshkov, N.I., Katzenellenbogen, J.A., Lyut, L.G., et al., in Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine, Padova: SGEditorial, 2002, pp. 127–130.

    Google Scholar 

  12. Gorshkov, N.I., Miroslavov, A.E., Lumpov, A.A., et al., Radiokhimiya, 2003, vol. 45, no.2, pp. 116–118.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Khlopin Radium Institute, Research and Production Association, St. Petersburg, Russia

    N. I. Gorshkov, A. A. Lumpov, A. E. Miroslavov & D. N. Suglobov

Authors
  1. N. I. Gorshkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. A. Lumpov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. E. Miroslavov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. N. Suglobov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

__________

Translated from Radiokhimiya, Vol. 47, No. 1, 2005, pp. 44–48.

Original Russian Text Copyright © 2005 by Gorshkov, Lumpov, Miroslavov, Suglobov.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gorshkov, N.I., Lumpov, A.A., Miroslavov, A.E. et al. 2 + 1 Chelating Systems for Binding Organometallic Fragment Tc(CO) +3 . Radiochemistry 47, 45–49 (2005). https://doi.org/10.1007/s11137-005-0045-2

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11137-005-0045-2

Keywords

Search

Navigation