Abstract
Purpose
Quality of life (QoL) and prognosis of lung cancer (LC) patients are poor. Previous studies focused less on the relationship between genetic factors and the QoL of LC patients. The current study is intended to explore the association of SNPs and haplotypes of BRCA1 and the QoL and survival of patients with LC.
Methods
QOL of 291 non-small-cell LC patients was measured by EORTC Core Quality of Life Questionnaire (QLQ-C30) and EORTC Quality of Life Questionnaire‐Lung Cancer 13 (QLQ-LC13) before discharge. Three tag SNPs of the BRCA1 gene (rs1799966, rs3737559, rs8067269) were detected using an improved multiplex ligation detection reaction (iMLDR) technique. Haplotype analysis was conducted using the software Haploview 4.2. The patients’ survival was followed up every six months until March 2019.
Results
rs8067269 was associated with physical functioning (β = 7.97, p = 0.024) and diarrhea (Odds ratios (OR) 0.32, p = 0.042). rs1799966–rs3737559–rs8067269 haplotype was associated with several domains of QoL, including physical functioning (TCG vs. CCA: β = 6.21, p = 0.010), worse dyspnea (TCG vs. CTA: OR 2.05, p = 0.031) and peripheral neuropathy (TCG vs. CTA: OR 3.91, p = 0.030). BRCA1 rs1799966 CC genotype, rs8067269 AA genotype and CCA haplotype were associated with longer survival time of LC patients (p < 0.05).
Conclusion
SNPs and haplotypes of BRCA1 gene were associated with the QoL and survival of patients with LC. Patients with certain genotypes and haplotypes (i.e., rs8067269 AA genotype, or CCA haplotype) had better QoL and prognosis.
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Data availability
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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Funding
This study was funded by “National Science Foundation of China” (Grant Number 81602734).
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Dr. Su contributed to experimental operation, data collection and analysis, and wrote the first draft. Mr. Sun, Miss Lu and Miss He contributed to questionnaire survey. Dr. Xiao and Miss He contributed to follow-up. Dr. Yang and Dr. Tang supervised data collection and analysis, critically read and revised this manuscript, and takes the responsibility of this paper. All authors meet authorship criteria and approve the final version of the manuscript.
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Approval was obtained from the ethics committee of Navy Medical University, China. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.
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Su, T., Sun, H., Lu, X. et al. Genetic polymorphisms and haplotypes of BRCA1 gene associated with quality of life and survival among patients with non-small-cell lung cancer. Qual Life Res 29, 2631–2640 (2020). https://doi.org/10.1007/s11136-020-02509-2
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DOI: https://doi.org/10.1007/s11136-020-02509-2