Abstract
Objectives
To evaluate quality of life (QoL) and related variables in patients with ankylosing spondylitis (AS), a chronic inflammatory disease of the spine.
Methods
Nine-hundred and sixty-two patients with AS from the Turkish League Against Rheumatism AS Registry, who fulfilled the modified New York criteria, were enrolled. The patients were evaluated using the Assessment of SpondyloArthritis International Society core outcome domains including Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), fatigue (BASDAI-question 1), pain (last week/spine/due to AS), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Radiology Index (BASRI), Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) and two QoL questionnaires (the disease-specific ASQoL and generic the Short Form-36 [SF-36]).
Results
The mean ASQoL score was 7.1 ± 5.7. SF-36 subscales of general health, physical role and bodily pain had the poorest scores. ASQoL was strongly correlated with disease duration, BASDAI, fatigue, BASFI, BASMI, BASRI, MASES, pain and SF-36 subscales (P < 0.001). SF-36 subscales were also strongly correlated with BASDAI and BASFI. Advanced educational status and regular exercise habits positively affected QoL, while smoking negatively affected QoL.
Conclusions
In patients with AS, the most significant variables associated with QoL were BASDAI, BASFI, fatigue and pain. ASQoL was noted to be a short, rapid and simple patient-reported outcome (PRO) instrument and strongly correlated with SF-36 subscales.
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References
Bodur, H., Ataman, S., Akbulut, L., et al. (2008). Characteristics and medical management of patients with rheumatoid arthritis and ankylosing spondylitis. Clinical Rheumatology, 27, 1119–1125. doi:10.1007/s10067-008-0877-1.
Bostan, E. E., Borman, P., Bodur, H., et al. (2003). Functional disability and quality of life in patients with ankylosing spondylitis. Rheumatology International, 23, 121–126.
Doward, L. C., Spoorenberg, A., Cook, S. A., et al. (2003). Development of the ASQoL: A quality of life instrument specific to ankylosing spondylitis. Annals of the Rheumatic Diseases, 62, 20–26. doi:10.1136/ard.62.1.20.
van der Heijde, D. M., Revicki, D. A., Gooch, K. L., et al. (2009). Physical function, disease activity, and health-related quality-of-life outcomes after 3 years of adalimumab treatment in patients. Arthritis Research & Therapy, 11, R124. doi:10.1186/ar2790.
Sieper, J., Rudwaleit, M., Baraliakos, X., et al. (2009). The assessment of spondyloarhritis international society (ASAS) handbook: A guide to assess spondyloarthritis. Annals of the Rheumatic Diseases, 68, 114–144. doi:10.1136/ard.2008.104018.
Karatepe, A. G., Akkoc, Y., Asar, S., et al. (2005). The Turkish versions of the Bath Ankylosing Spondylitis and Dougados functional indices: Reliability and validity. Rheumatology International, 25, 612–618. doi:10.1007/s00296-004-0481-x.
Akkoc, Y., Karatepe, A. G., Asar, S., et al. (2005). A Turkish version of the Bath Ankylosing Spondylitis disease activity index: Reliability and validity. Rheumatology International, 25, 280–284. doi:10.1007/s00296-003-0432-y.
Heuft-Dorenbosch, L., Spoorenberg, A., van Tubergen, A., et al. (2003). Assessment of enthesitis in ankylosing spondylitis. Annals of the Rheumatic Diseases, 62, 127–132. doi:10.1136/ard.62.2.127.
Braun, J., Golder, W., Bollow, M., Sieper, J., & van der Heijde, D. (2002). Imaging and scoring in ankylosing spondylitis. Clinical and Experimental Rheumatology, 20(Suppl. 28), S178–S184.
Duruoz, T., Doward, L., Cerrahoglu, L., et al. Translation and validation of the Turkish version of the ankylosing spondylitis quality of life (ASQoL) Questionnaire. EULAR 2008 Abstract Book, Paris, France, 11–14 June 2008.
Demirsoy, A. C. (1999). The MOS SF-36 health survey: A validation study with a Turkish sample. Thesis, Bogazici University, İstanbul.
Salaffi, F., Carotti, M., Gasparini, S., et al. (2009). The health-related quality of life in rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis: A comparison with a selected sample of healthy people. Health and Quality of Life Outcomes, 7, 25. doi:10.1186/1477-7525-7-25.
Zhao, L. K., Liao, Z. T., Li, C. H., et al. (2007). Evaluation of quality of life using ASQoL questionnaire in patients with ankylosing spondylitis in a Chinese population. Rheumatology International, 27, 605–611. doi:10.1007/s00296-006-0267-4.
Ozgül, A., Peker, F., Taskaynatan, M. A., et al. (2006). Effect of ankylosing spondylitis on health-related quality of life and different aspects of social life in young patients. Clinical Rheumatology, 25, 168–174. doi:10.1007/s10067-005-1150-5.
Turan, Y., Duruöz, M. T., & Cerrahoglu, L. (2007). Quality of life in patients with ankylosing spondylitis: A pilot study. Rheumatology International, 27, 895–899. doi:10.1007/s00296-007-0315-8.
Günaydin, R., Göksel Karatepe, A., Ceşmeli, N., et al. (2009). Fatigue in patients with ankylosing spondylitis: relationship with disease-specific variables, depression, and sleep disturbance. Clinical Rheumatology, 28, 1045–1051. doi:10.1007/s10067-009-1204-1.
Ward, M. M. (2002). Predictor of the progression of functional disability in patients with ankylosing spondylitis. Journal of Rheumatology, 29, 1420–1425.
Acknowledgments
The authors express their gratitude to all members of the TRASD AS Study group for their cooperation and to Wyeth/Pfizer Company for the registery sponsorship.
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Filiz M. Sertpoyraz, İzmir Tepecik Training & Research Hospital; Barış Nacır Ankara Training & Research Hospital; Ömer Faruk Şendur, Adnan Menderes University School of Medicine; Melek Sezgin Mersin University School of Medicine, Ferda Özkan, Ankara Physical Medicine and Rehabilitation Training & Research Hospital, Figen Ayhan Ankara Training & Research Hospital; Ali Sallı Selçuk University School of Medicine; O. Hakan Gündüz, Marmara University School of Medicine; Sami Hizmetli, Cumhuriyet University School of Medicine; Funda Atamaz, Ege University School of Medicine.
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Bodur, H., Ataman, Ş., Rezvani, A. et al. Quality of life and related variables in patients with ankylosing spondylitis. Qual Life Res 20, 543–549 (2011). https://doi.org/10.1007/s11136-010-9771-9
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DOI: https://doi.org/10.1007/s11136-010-9771-9