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Phytochemical Constituents from the Seeds of Capsella bursa-pastoris and Their Antioxidant Activities

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Abstract

Phytochemical investigation of 70% EtOH extract of the seeds of Capsella bursa-pastoris led to the isolation of a new cyclobutane organic acid (1), and fourteen known compounds, including two organosulfur compounds (2, 3), two quinonoids (4, 5), five flavonoids (6-10), three sterols (11-13) and two other types (14, 15). The structures of the compounds were elucidated by extensive spectroscopic analyses as well as comparison of their spectroscopic data with those reported in the literature. The antioxidant capacities of all compounds and extractive fractions were evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging test and ferric reducing antioxidant power (FRAP) assay. Then the antioxidative substances were evaluated for their neuroprotective effects against H2O2-induced HT22 cell injury. The results indicated the strong scavenging ability to free radical of the extractive fractions and compounds 1-3, 8-10 and 13, and the ferric reducing antioxidant power of the extractive fractions and compounds 1-3, 8 and 10, which were close to or higher than that of the positive control trolox. The EtOAc fraction, n-BuOH fraction, and compounds 1, 3 and 8 can protect HT-22 cells from oxidative damage.

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All relevant data are within the manuscript and its supplementary material, and are also available from the corresponding author on reasonable request.

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Author notes

  1. Ti-Qiang Zhou and Zhen-Zhen Wei contributed equally to this work.

Authors and Affiliations

  1. Advanced Research Institute of Multidisciplinary Science, School of Life Science, School of Medical Technology, Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, Beijing, 100081, China

    Ti-Qiang Zhou

  2. Jiangxi Province Key Laboratory of TCM Etiopathogenisis, Research center for differention and development of TCM Basic Theory, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China

    Zhen-Zhen Wei

  3. Department of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing, 100850, China

    Zhen-Zhen Wei, Jin-Rui Zhang, Jia-Hui Dong, Chun-Ying Liu, Cong-Zhi Jiang, Zi-Ming Xia, Si-Fan Liu, Min Li, Guang-jie Zhang, Li Chen, Ying Tian, Bin Li & Shu-Chen Liu

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Contributions

Ti-Qiang Zhou and Zhen-Zhen Wei wrote the main manuscript text and prepared Figs. 1, 2, 3, 4 and 5; Jin-Rui Zhang, Jia-Hui Dong, Chun-Ying Liu and Cong-Zhi Jiang taken the formal analysis of the manuscript; Zi-Ming Xia, Si-Fan Liu, Min Li and Guang-jie Zhang curated the related data; and Li Chen, Ying Tian, Bin Li, and Shu-Chen Liu reviewed and edited the manuscript. All authors reviewed the manuscript.

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Correspondence to Ying Tian, Bin Li or Shu-Chen Liu.

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Zhou, TQ., Wei, ZZ., Zhang, JR. et al. Phytochemical Constituents from the Seeds of Capsella bursa-pastoris and Their Antioxidant Activities. Plant Foods Hum Nutr 78, 776–782 (2023). https://doi.org/10.1007/s11130-023-01097-z

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