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Antihypertensive Effect and Safety Evaluation of Rice Bran Hydrolysates from Sang-Yod Rice

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Abstract

Rice bran hydrolysates contain highly nutritional proteins and beneficial phytochemicals. Sang-Yod rice bran hydrolysates (SRH) extracted from red pigmented rice is a rich source of nutrients and phenolic compounds. The present study evaluated the antihypertensive effect of SRH and its safety in Sprague-Dawley rats. Hypertension was induced in male rats by administration of L-NAME (50 mg/kg/day) in drinking water for three weeks, and the antihypertensive effect of SRH was evaluated. Treatment of SRH (250 or 500 mg/kg) significantly reduced arterial blood pressure and improved hemodynamic parameters. The antihypertensive effect was associated with decreased oxidative stress, suppressed p47phox NADPH oxidase expression, increased nitric oxide bioavailability and decreased angiotensin II level and ACE activity. The SRH was shown to be safe after feeding male and female rats with a rodent diet containing 1.5% SRH for 90 days. Overall, these findings suggest that SRH is safe and may help to prevent hypertension.

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Acknowledgements

This research was supported by the Khon Kaen University Research Grants [No. 6100049, No.6200037], and the National Research Council of Thailand (NRCT) and the Agricultural Research Development Agency (ARDA) under the Thailand Research Organization Network (TRON; CRP5507020810), Thailand. We would like to thank Dr. Justin Thomas Reese for editing the manuscript via the Publication Clinic KKU, Thailand.

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Authors and Affiliations

  1. Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

    Gulladawan Jan-on, Weerapon Sangartit, Poungrat Pakdeechote & Upa Kukongviriyapan

  2. Cardiovascular Research Group, Khon Kaen University, Khon Kaen, 40002, Thailand

    Gulladawan Jan-on, Weerapon Sangartit, Poungrat Pakdeechote & Upa Kukongviriyapan

  3. Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

    Veerapol Kukongviriyapan

  4. Division of Physiology, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

    Ketmanee Senaphan

  5. Faculty of Allied Health Sciences, Burapha University, Chonburi, 20131, Thailand

    Orachorn Boonla

  6. Department of Food Technology, Faculty of Agro-Industry, Prince of Songkla University, Songkla, 90112, Thailand

    Chakree Thongraung

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  1. Gulladawan Jan-on
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Correspondence to Upa Kukongviriyapan.

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Jan-on, G., Sangartit, W., Pakdeechote, P. et al. Antihypertensive Effect and Safety Evaluation of Rice Bran Hydrolysates from Sang-Yod Rice. Plant Foods Hum Nutr 75, 89–95 (2020). https://doi.org/10.1007/s11130-019-00789-9

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