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The role of plant mitochondria in the biosynthesis of coenzymes

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Abstract

This last decade, many efforts were undertaken to understand how coenzymes, including vitamins, are synthesized in plants. Surprisingly, these metabolic pathways were often “quartered” between different compartments of the plant cell. Among these compartments, mitochondria often appear to have a key role, catalyzing one or several steps in these pathways. In the present review we will illustrate these new and important biosynthetic functions found in plant mitochondria by describing the most recent findings about the synthesis of two vitamins (folate and biotin) and one non-vitamin coenzyme (lipoate). The complexity of these metabolic routes raise intriguing questions, such as how the intermediate metabolites and the end-product coenzymes are exchanged between the various cellular territories, or what are the physiological reasons, if any, for such compartmentalization.

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Abbreviations

ADC:

Aminodeoxychorismate

Ado· :

5′-deoxyadenosyl radical

AdoMet:

S-adenosylmethionine

Adx1:

Adrenodoxin-like protein

AdxR:

Adrenodoxin reductase

BCKDH:

Branched-chain α-ketoacid dehydrogenase

DAPA:

7,8-diamino pelargonic acid

DHFR:

Dihydrofolate reductase

E2:

Dihydrolipoamide acyltransferase subunits

DHFS:

Dihydrofolate synthetase

DHPS:

Dihydropteroate synthase

DTB:

Dethiobiotin

FAS:

Fatty acid synthase

FPGS:

Folylpolyglutamate synthase

GDC:

Glycine decarboxylase

HPPK:

Hydroxymethyldihydropterin pyrophosphokinase

H4F:

Tetrahydrofolate

H4FGlun:

Tetrahydrofolate with n glutamates

H2F:

Dihydrofolate

KAPA:

7-keto-8-amino pelargonic acid

KAS:

β-ketoacyl acyl carrier protein synthase

KGDH:

α-ketoglutarate dehydrogenase

LCMS:

Liquid chromatography coupled to mass spectrometry

mtFAS:

mitochondrial fatty acid synthase

Nfs1:

Mitochondrial cystein desulfurase

pABA:

para-aminobenzoate

PDH:

Pyruvate dehydrogenase

PLP:

Pyridoxal 5′-phosphate

ACP:

Acyl carrier protein

SHMT:

Serine hydroxymethyl transferase

TS:

Thymidylate synthase

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Acknowledgments

I (RD) must say that the best year of my life was undoubtedly the year I spent at the Scripps Institution of Oceanography in Andy’s company. It was both a delight and a privilege.

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  1. Laboratoire de Physiologie Cellulaire Végétale, Institut de Recherches en Technologies et Sciences pour le Vivant, UMR5168 CEA/CNRS/INRA/Université Joseph Fourier Grenoble, CEA-Grenoble, 17 rue des Martyrs, Grenoble Cedex 9, 38054, France

    Fabrice Rébeillé, Claude Alban, Jacques Bourguignon, Stéphane Ravanel & Roland Douce

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  1. Fabrice Rébeillé
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  2. Claude Alban
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  3. Jacques Bourguignon
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  4. Stéphane Ravanel
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Correspondence to Fabrice Rébeillé.

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Rébeillé, F., Alban, C., Bourguignon, J. et al. The role of plant mitochondria in the biosynthesis of coenzymes. Photosynth Res 92, 149–162 (2007). https://doi.org/10.1007/s11120-007-9167-z

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