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AtRLI2 is an Endogenous Suppressor of RNA Silencing

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Abstract

RNA silencing is a mechanism involved in gene regulation during development and anti-viral defense in plants and animals. Although many viral suppressors of this mechanism have been described up to now, this is not the case for endogenous suppressors. We have identified a novel endogenous suppressor in plants: RNase L inhibitor (RLI) of Arabidopsis thaliana. RLI is a very conserved protein among eukaryotes and archaea. It was first known as component of the interferon-induced mammalian 2′–5′ oligoadenylate (2–5A) anti-viral pathway. This protein is in several organisms responsible for essential functions, which are not related to the 2–5A pathway, like ribosome biogenesis and translation initiation. Arabidopsis has two RLI paralogs. We have described in detail the expression pattern of one of these paralogs (AtRLI2), which is ubiquitously expressed in all plant organs during different developmental stages. Infiltrating Nicotiana benthamiana green fluorescent protein (GFP)-transgenic line with Agrobacterium strains harboring GFP and AtRLI2, we proved that AtRLI2 suppresses silencing at the local and at the systemic level, reducing drastically the amount of GFP small interfering RNAs.

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Abbreviations

2–5A:

2′–5′ oligoadenylate

Ago:

Argonaute protein

AtRLI2 :

Arabidopsis thaliana gene At4g19210

dpi:

days post-infiltration

dsRNA:

double-stranded RNA

GFP:

green fluorescent protein

nt:

nucleotide

RISC:

RNA-induced silencing complex

RdRP:

RNA-dependent RNA polymerase

RLI:

RNase L inhibitor

RNAi:

RNA interference

RPA:

RNase protection assay

siRNA:

small interfering RNA

UTR:

untranslated region

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Authors and Affiliations

  1. Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, 19086, Tallinn, Estonia

    Cecilia Sarmiento, Lenne Nigul, Jekaterina Kazantseva, Marju Buschmann & Erkki Truve

  2. National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, 12618, Tallinn, Estonia

    Cecilia Sarmiento, Lenne Nigul, Jekaterina Kazantseva, Marju Buschmann & Erkki Truve

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  1. Cecilia Sarmiento
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  2. Lenne Nigul
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  3. Jekaterina Kazantseva
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  4. Marju Buschmann
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Correspondence to Cecilia Sarmiento.

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Sarmiento, C., Nigul, L., Kazantseva, J. et al. AtRLI2 is an Endogenous Suppressor of RNA Silencing. Plant Mol Biol 61, 153–163 (2006). https://doi.org/10.1007/s11103-005-0001-8

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