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A Plant Orthologue of RNase L Inhibitor (RLI) Is Induced in Plants Showing RNA Interference

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Abstract

RNase L inhibitors (RLIs) correspond to a group of soluble proteins from the large ATP binding cassette (ABC) family of proteins. Structurally, RLIs have an N-terminal Fe–S domain and two nucleotide binding domains. Orthologous RLI sequences with more than 48% identity have been found from Archea to Eukaryota, but have not as yet been identified in Eubacteria. Some organisms, like Arabidopsis thaliana and human, have paralogous genes with differential expression patterns, the function of which remains to be determined. Expression of Arabidopsis RLI2 was slightly increased in transgenic plants showing RNA interference, suggesting a role in this pathway

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Acknowledgments

The authors want to thank FAPESP for accessing the SUCEST data bank. A.S.K. Braz was supported by a doctoral fellowship and R. Margis by a postdoctoral fellowship from Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq.

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Authors and Affiliations

  1. LGMV—Laboratório de Genética Molecular Vegetal, Departamento de Genética, Instituto de Biologia, CCS, Universidade Federal do Rio Janeiro, 21944–970, Ilha do Fundão, Rio de Janeiro, Brasil

    Antonio Sergio Kimus Braz & Rogério Margis

  2. Departamento de Bioquímica, Instituto de Química, UFRJ, Rio de Janeiro,, Brasil

    Rogério Margis

  3. Plant Industry, CSIRO, Canberra, ACT, Australia

    Jean Finnegan & Peter Waterhouse

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  1. Antonio Sergio Kimus Braz
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  2. Jean Finnegan
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  3. Peter Waterhouse
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  4. Rogério Margis
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Correspondence to Rogério Margis.

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Braz, A.S.K., Finnegan, J., Waterhouse, P. et al. A Plant Orthologue of RNase L Inhibitor (RLI) Is Induced in Plants Showing RNA Interference. J Mol Evol 59, 20–30 (2004). https://doi.org/10.1007/s00239-004-2600-4

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