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Predictive value of macular ganglion cell-inner plexiform layer thickness in visual field defect of pituitary adenoma patients: a case-control study

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Abstract

Objective

The present study explored the association between preoperative macular ganglion cell-inner plexiform layer thickness (GCIPL) and retinal nerve fiber layer thickness (RNFL) measured by optical coherence tomography (OCT) and the recovery of visual field (VF) defect after surgery in pituitary adenoma patients.

Methods

This case-control study included patients with pituitary adenoma in the Neurosurgery Department of Shanxi Provincial People’s Hospital between October 2019 and June 2021. Cranial MRI examination, three-dimensional OCT, and VF testing (Humphrey Field Analyzer II750) were performed before and at 6months after the surgery.

Results

Fifty-three pituitary adenoma patients (81 eyes) were enrolled; 15 patients (23 eyes) were in the visual field did not recover group (VFNR), and 38 patients (58 eyes) were in the visual field recovered group (VFR). The temporal RNFL (P = 0.002) and average RNFL (P = 0.009) in the VFNR group were significantly lower than in the VFR group. The superior nasal GCIPL (P = 0.001), inferior nasal GCIPL (P = 0.001) and average GCIPL (P = 0.01) were significantly lower in the VFNR group than in the VFR group (all P < 0.01).The multivariable logistic regression analysis showed that nasal inferior GCIPL was an independent risk factor for VF recovery (odds ratio (OR) = 1.376,95% confidence interval (CI):1.089-1.739,P = 0.007). In the received operating characteristics (ROC) analysis, the area under the ROC curve (AUROCs) was the highest for nasal inferior GCIPL (AUROC = 0.739).

Conclusions

In patients who underwent resection of pituitary adenoma, nasal inferior GCIPL was an independent risk factor of visual field defect recover after surgery.

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References

  1. Russ S, Anastasopoulou C, Shafiq I (2022) Pituitary Adenoma

  2. Ntali G, Wass JA (2018) Epidemiology, clinical presentation and diagnosis of non-functioning pituitary adenomas. Pituitary 21(2):111–118. https://doi.org/10.1007/s11102-018-0869-3

    Article  PubMed  Google Scholar 

  3. AlMalki MH, Ahmad MM, Brema I et al (2020) Contemporary Management of Clinically Non-functioning Pituitary Adenomas: A Clinical Review. Clin Med Insights:Endocrinology Diabetes 13:1–13. https://doi.org/10.1177/1179551420932921

    Article  Google Scholar 

  4. Bialer OY, Cohen GN,Toledano H et al (2013) Retinal NFL thinning on OCT correlates with visual field loss in pediatric craniopharyngioma. Can J Ophthalmol 48(6):494–499. .https://doi.org/10.101/j.jcjo.2013.05.00

    Article  Google Scholar 

  5. Banc A, Stan C, Florian IS (2018) Optical coherence tomography as a marker of vision in children with optic pathway gliomas. Childs Nerv Syst 34(1):51–60. https://doi.org/10.1007/s00381-017-3578-8

    Article  PubMed  Google Scholar 

  6. Jariyakosol S, Peragallo JH (2015) The Effects of Primary Brain Tumors on Vision and Quality of Life in Pediatric Patients. Semin Neurol 35(5):587–598. https://doi.org/10.1055/s-0035-1563571

    Article  PubMed  Google Scholar 

  7. Peragallo JH (2019) Visual function in children with primary brain tumors. Curr Opin Neurol 32(1):75–81. https://doi.org/10.1097/WCO.0000000000000644

    Article  PubMed  PubMed Central  Google Scholar 

  8. Bhende M, Shetty S, Parthasarathy MK et al (2018) Optical coherence tomography: A guide to interpretation of common macular diseases. Indian J Ophthalmol 66(1):20–35. https://doi.org/10.4103/ijo.IJO_902_17

    Article  PubMed  PubMed Central  Google Scholar 

  9. Fujii K, Kubo T,Otake H et al (2022) Expert consensus statement for quantitative measurement and morphological assessment of optical coherence tomography: update 2022. Cardiovasc Interv Ther 37(2):248–254. https://doi.org/10.1007/s12928-022-00845-3

    Article  PubMed  Google Scholar 

  10. Hood DC( (2019) Does Retinal Ganglion Cell Loss Precede Visual Field Loss in Glaucoma? J Glaucoma 28(11):945–951. https://doi.org/10.1097/IJG.0000000000001380

    Article  PubMed  PubMed Central  Google Scholar 

  11. Asensio-Sanchez VM, Foncubierta J (2016) Progressive loss of vision caused by asymptomatic pituitary macroadenoma: role of OCT. Int Med Case Rep J 9:291–293. https://doi.org/10.2147/IMCRJ.S113339

    Article  PubMed  PubMed Central  Google Scholar 

  12. Danesh-Meyer HV, Wong A, Papchenko T et al (2015) Optical coherence tomography predicts visual outcome for pituitary tumors. J Clin Neurosci 22(7):1098–1104. https://doi.org/10.1016/j.jocn.2015.02.001

    Article  PubMed  Google Scholar 

  13. Jeong AR, Kim EY,Kim NR (2016) Preferential Ganglion Cell Loss in the Nasal Hemiretina in Patients With Pituitary Tumor. J Neuroophthalmol 36(2):152–155. https://doi.org/10.1097/WNO.0000000000000331

    Article  PubMed  Google Scholar 

  14. Tieger MG, Hedges TR, Ho J et al (2017) Ganglion Cell Complex Loss in Chiasmal Compression by Brain Tumors. J Neuroophthalmol 37(1):7–12. https://doi.org/10.1097/WNO.0000000000000424

    Article  PubMed  PubMed Central  Google Scholar 

  15. Cennamo G, Auriemma RS,Cardone D et al (2015) Evaluation of the retinal nerve fibre layer and ganglion cell complex thickness in pituitary macroadenomas without optic chiasmal compression. Eye (Lond) 29(6):797–802. https://doi.org/10.1038/eye.2015.35

    Article  CAS  Google Scholar 

  16. Yum HR, Park SH, Park Hae-Young L et al (2016) Macular Ganglion Cell Analysis Determined by Cirrus HD Optical Coherence Tomography for Early Detecting Chiasmal Compression. PLoS ONE 11(4):e0153064. https://doi.org/10.1371/journal.pone.0153064

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Shin HY, Park HY, Jung KI et al (2013) Comparative study of macular ganglion cell-inner plexiform layer and peripapillary retinal nerve fiber layer measurement: structure-function analysis. Invest Ophthalmol Vis Sci 54(12):7344–7353. https://doi.org/10.1167/iovs.13-12667

    Article  PubMed  Google Scholar 

  18. Grkovic D, Davidovic S (2016) Prognotic factors for postoperative visual outcome in surgically treated suprasellar meningiomas. Med Pregl 69(5–6):146–152. https://doi.org/10.2298/mpns1606146g

    Article  PubMed  Google Scholar 

  19. Sun MZhangZQ, Ma CY et al (2017) Predictive factors of visual function recovery after pituitary adenoma resection: a literature review and Meta-analysis. Int J Ophthalmol 10(11):1742–1750. https://doi.org/10.18240/ijo.2017.11.17

    Article  PubMed  PubMed Central  Google Scholar 

  20. Zhang XMaJ, Wang YH et al (2019) The correlation of ganglion cell layer thickness with visual field defect in non-functional pituitary adenoma with chiasm compression]. Zhonghua Yan Ke Za Zhi 55(3):186–194. https://doi.org/10.3760/cma.j.issn.0412-4081.2019.03.007

    Article  CAS  PubMed  Google Scholar 

  21. Danesh-Meyer HV, Papchenko T, Savino PJ et al (2008) In vivo retinal nerve fiber layer thickness measured by optical coherence tomography predicts visual recovery after surgery for parachiasmal tumors. Invest Ophthalmol Vis Sci 49(5):1879–1885. https://doi.org/10.1167/iovs.07-1127

    Article  Google Scholar 

  22. Yoneoka Y, Hatase T, Watanabe N et al (2015) Early morphological recovery of the optic chiasm is associated with excellent visual outcome in patients with compressive chiasmal syndrome caused by pituitary tumors. Neurol Res 37(1):1–8. https://doi.org/10.1179/1743132814Y.0000000407

    Article  PubMed  Google Scholar 

  23. Monteiro ML, Zambon BK,Cunha LP (2010) Predictive factors for the development of visual loss in patients with pituitary macroadenomas and for visual recovery after optic pathway decompression. Can J Ophthalmol 45(4):404–408. https://doi.org/10.3129/i09-276

    Article  PubMed  Google Scholar 

  24. Moon CH, Kim SC (2011) BT Visual Prognostic Value of Optical Coherence Tomography and Photopic Negative Response in Chiasmal Compression. Invest Ophthalmol Vis Sci 52(11):8527.https://doi.org/10.1167/iovs.11-8034

  25. Ohkubo S, Higashide C, Takeda H et al (2011) Relationship between macular ganglion cell complex parameters and visual fifield parameters after tumor resection in chiasmal compression. Jpn J Ophthalmol 56:68–75. https://doi.org/10.1007/s10384-011-0093-4

    Article  Google Scholar 

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Funding

This study was supported by the 136 Project of Shanxi Provincial People’s Hospital.

Author information

Authors and Affiliations

  1. Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmolgy and Visual Science Key Laboratory, Beijing Tongren Eye Center, Capital Medical University, No.17 Hougou Lane, Chongnei Street, 100005, Beijing, People’s Republic of China

    Li Xia & Peng Xiaoyan

  2. Department of Ophthalmology, Shanxi Provincial People’s Hospital, No.29 Twin Towers, YingZe District, 030000, Taiyuan, People’s Republic of China

    Li Xia, Xie Wenfang & Zhang Wei

  3. Department of neurology, Shanxi Provincial People’s Hospital, No.29 Twin Towers, YingZe District, 030000, Taiyuan, People’s Republic of China

    Jia Wenhui

  4. Infectious disease department, Shanxi Provincial People’s Hospital, No.29 Twin Towers, YingZe District, 030000, Taiyuan, People’s Republic of China

    Yang Xiaowen

  5. Department of nuclear magnetic, Shanxi Provincial People’s Hospital, No.29 Twin Towers, YingZe District, 030000, Taiyuan, People’s Republic of China

    Hu Yanjun

Authors
  1. Li Xia
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  2. Jia Wenhui
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  3. Yang Xiaowen
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  4. Xie Wenfang
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  5. Zhang Wei
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  6. Hu Yanjun
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  7. Peng Xiaoyan
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Contributions

LX ,XYP and WHJ performed the initial experimental design, WFX, ZW and YJH helped to collect the cases and completed relevant inspection, LX produced the first draft of the manuscript and figures.XWY reviewed statistical analysis,XYP and WHJ edited the manuscript, contributing to the final version sent for approval. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Peng Xiaoyan.

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Conflict of interest

The authors have no potential conflicts of interest to disclose.The participants were informed of the study objectives and signed the informed consent form.

Research involving human participants, their data or biological material

This study was approved by the Ethics Committee of Shanxi Provincial People’s Hospital and was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Xia, L., Wenhui, J., Xiaowen, Y. et al. Predictive value of macular ganglion cell-inner plexiform layer thickness in visual field defect of pituitary adenoma patients: a case-control study. Pituitary 25, 667–672 (2022). https://doi.org/10.1007/s11102-022-01248-6

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  • DOI: https://doi.org/10.1007/s11102-022-01248-6

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