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Analysis of factors affecting visual field recovery following surgery for pituitary adenoma

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Abstract

Purpose

To analyze the factors influencing visual field recovery in patients with pituitary adenoma following surgical treatment.

Methods

We retrospectively reviewed 144 eyes of 72 patients with pituitary adenoma who had been followed up for more than 6 months following surgery between January 2016 and December 2019. Pre and postoperative visual acuity, visual field test and retinal nerve fiber layer (RNFL) thickness were investigated. We defined recovery of visual field defects as being an improvement in mean deviation (MD) of 2 dB or more.

Result

The average age of the 72 patients (144 eyes) was 51.94 ± 14.69 years, making for 37 patients in the recovery group and 35 patients in the non-recovery group. Preoperative MD, pattern standard deviation (PSD), and visual field indexes (VFI) were negatively correlated to postoperative MD, PSD and VFI changes and positively correlated to postoperative MD, PSD, and VFI values. Using multiple regression analysis, a shorter duration of symptoms (Odds ratio [OR], 0.990; p = 0.033), higher preoperative MD values (OR, 0.871; p = 0.025), and thicker temporal RNFL (OR, 1.068; p = 0.048) were associated with a visual field recovery following surgery.

Conclusions

The prognosis for visual field recovery is favorable for patients who have a short period from symptom onset to surgery, a higher MD value of preoperative VF, and a thicker peripapillary temporal RNFL thickness. Therefore, the preoperative MD, temporal RNFL thickness, and the symptom period can be predictive variables affecting postoperative visual field recovery.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

OCT:

Optical coherence tomography

RNFL:

Retinal nerve fiber layer

VF:

Visual field

TSA-TR:

Transsphenoidal approach-tumor resection

MRI:

Magnetic resonance imaging

MD:

Mean deviation

log MAR:

Logarithm of the minimum angle of resolution

BCVA:

Best corrected visual acuity

PSD:

Pattern standard deviation

VFI:

Visual field index

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Acknowledgements

This manuscript has not been published or presented elsewhere in part or in entirety and is not under consideration by another journal.

Funding

This study was supported by a 2020 research grant from Pusan National University Yangsan Hospital.

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Authors and Affiliations

  1. Department of Ophthalmology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, 20-Geumo-ro, Mulgeum-eup, Yangsan, Gyeongsangnam-do, 50612, South Korea

    Su Hwan Park, Min Seung Kang, Sang Yoon Kim, Ji-Eun Lee, Jong Hoon Shin & Su Jin Kim

  2. Department of Ophthalmology, Pusan National University School of Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea

    Heeyoung Choi

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  1. Su Hwan Park
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  2. Min Seung Kang
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  4. Ji-Eun Lee
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Contributions

KSJ and CHY are responsible for study design and acquisition of the clinical information. PSH and KSJ are responsible for manuscript preparation. PSH, KMS, and KSY are responsible for date analysis. LJE and CHY are responsible for reviewing the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Su Jin Kim.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest, or other equity interest, or non-financial interest in the subject matter or materials discussed in this manuscript.

Informed consent

The institutional review board had approved the research (IRB Number: 05-2020-143). This study was retrospective, and the informed consent on subject was waived.

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Park, S.H., Kang, M.S., Kim, S.Y. et al. Analysis of factors affecting visual field recovery following surgery for pituitary adenoma. Int Ophthalmol 41, 2019–2026 (2021). https://doi.org/10.1007/s10792-021-01757-6

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  • DOI: https://doi.org/10.1007/s10792-021-01757-6

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