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Gut microbiota in patients with newly diagnosed acromegaly: a pilot cross-sectional study

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Abstract

Purpose

Microbiota has crucial biological importance for human well-being. Bidirectional interaction exists between microbiota and the host, and there have been no studies investigating this interaction in patients with acromegaly. We aimed to analyze the composition of microbiota in patients with newly diagnosed acromegaly.

Method

Stool samples were obtained from the patients with newly diagnosed acromegaly in the Endocrinology Clinic of Erciyes University Medical School. The composition of microbiota was analyzed, and the results were compared to healthy volunteers matched to the patients in terms of age, gender and body mass index.

Results

Seven patients (three male, four female) with a mean age of 48 ± 17.6 years were included in the study. The stool analysis revealed a significantly lower bacterial diversity in the patients with acromegaly. Bacteroidetes phylum was predominating in the patient group, and Firmicutes/Bacteroidetes ratio was altered significantly. Bifidobacterium, Collinsella, Bacteroides, Butyricimonas, Clostridium, Oscillospira, and Dialister were predominating in the control group.

Conclusion

The gut microbiota is significantly altered in patients with newly diagnosed acromegaly. Further prospective studies are needed to elucidate the causative relationship between acromegaly, colorectal pathologies, and microbial alterations.

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Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Acknowledgments

We thank Professor Dr. Kursad Unluhizarci for critical reading of the manuscript.

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Authors and Affiliations

  1. Department of Endocrinology, School of Medicine, Erciyes University, Kayseri, Turkey

    Aysa Hacioglu, Zuleyha Karaca & Muhammed Emre Urhan

  2. Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey

    Aycan Gundogdu

  3. Genome and Stem Cell Center (GenKok), Erciyes University, Kayseri, Turkey

    Aycan Gundogdu & Ufuk Nalbantoglu

  4. Department of Computer Engineering, Erciyes University, Kayseri, Turkey

    Ufuk Nalbantoglu

  5. Department of Endocrinology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey

    Hatice Sebile Dokmetas

  6. Department of Endocrinology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey

    Serdar Sahin & Pinar Kadioglu

  7. Department of Endocrinology, School of Medicine, Yeditepe University, Istanbul, Turkey

    Fahrettin Kelestimur

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Pituitary Microbiom Study Group (PITMIT-SG)

Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Zuleyha Karaca, Aysa Hacioglu, Aycan Gundogdu, Ufuk Nalbantoglu and Muhammed Emre Urhan. The first draft of the manuscript was written by Aysa Hacioglu and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Fahrettin Kelestimur.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of Erciyes University School of Medicine (Approval Date: 24.07.2019, Approval Number: 2019/575).

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Hacioglu, A., Gundogdu, A., Nalbantoglu, U. et al. Gut microbiota in patients with newly diagnosed acromegaly: a pilot cross-sectional study. Pituitary 24, 600–610 (2021). https://doi.org/10.1007/s11102-021-01137-4

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