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What are critical outcome measures for patients receiving pituitary replacement following brain injury?

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Abstract

There are scant prospective studies defining improvements in critical outcome measures with hormone replacement in hypopituitarism secondary to brain injury. We review the tests of cognition and physical function and summarize their use for subjects that are deficient in anterior hormone production during anterior pituitary hormone replacement in brain injury and propose these as the minimal tests that are feasible for a physician to perform in a clinical setting. We summarize the studies conducted to assess outcome measures after brain injury and also report preliminary findings for improvements in cognition and physical function in subjects with brain injury and GH deficiency.

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Authors and Affiliations

  1. Department of Internal Medicine, Endocrinology Division, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, 77555-1188, USA

    Sorin G. Beca

  2. Departments of Physical Medicine and Rehabilitation, Neurosurgery and Psychology, Cardinal Hill Rehabilitation Hospital , University of Kentucky College of Medicine, 2050 Versailles Rd., Lexington, KY, 40504, USA

    Walter M. High Jr.

  3. Transitional Learning Center at Galveston, 1528 Post Office Street, Galveston, TX, 77550, USA

    Brent E. Masel

  4. Department of Physical Therapy, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, 77555-1144, USA

    Kurt A. Mossberg

  5. Department of Internal Medicine, University of Texas Medical Branch, 301 University Blvd., Galveston, TX, 77555-0569, USA

    Randall J. Urban

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  1. Sorin G. Beca
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  2. Walter M. High Jr.
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  3. Brent E. Masel
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  4. Kurt A. Mossberg
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  5. Randall J. Urban
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Correspondence to Randall J. Urban.

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Beca, S.G., High, W.M., Masel, B.E. et al. What are critical outcome measures for patients receiving pituitary replacement following brain injury?. Pituitary 15, 10–19 (2012). https://doi.org/10.1007/s11102-008-0133-3

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