Abstract
Marine algal-derived endophytic fungi (MAEF) have proven to be unabated sources of novel secondary metabolites with remarkable scaffold diversity, structural complexity, and significant bioactivity. The growing trend in the discovery of new secondary metabolites from MAEF has continued increasing over the last few years. Our previous review summarized a total of 182 secondary metabolites isolated from MAEF covering from 2002 to mid-2015. To update the latest studies of intriguing secondary metabolites of MAEF, this present review covered 196 newly-discovered metabolites of MAEF from the beginning of 2016 to the end of 2021, which were categorized into terpenes and steroids (including bisabolane-type sesquiterpenes, cyclonerane-type sesquiterpenes, diterpenes, sesterterpenes, meroterpenoids, and steroids), nitrogenated compounds (including diketopiperazines, peptides, and other N-containing compounds), polyketides (including azaphilones, tetramic acid derivatives, chromenes, and chromone derivatives), phenolic compounds, and carboxylic acids derivatives based on their putative biogenetic origins. Crucial insights into their chemical diversity and biological activities are provided herein.
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This work was supported by the Central Public-interest Scientific Institution Basal Research Fund (Y2022QC32 and Y2021XK25) and the Agricultural Science and Technology Innovation Program (ASTIP-TRIC05).
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Gao, LW., Zhang, P. An update on chemistry and bioactivities of secondary metabolites from the marine algal-derived endophytic fungi. Phytochem Rev 22, 587–614 (2023). https://doi.org/10.1007/s11101-022-09852-x
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DOI: https://doi.org/10.1007/s11101-022-09852-x