Background Metabolic syndrome is a cluster of factors that increase the risk of cardiovascular disease and include: diabetes and prediabetes, abdominal obesity, elevated triglycerides, low high-density lipoprotein cholesterol and high blood-pressure. However, the role of the pharmacist in the metabolic syndrome has not yet been fully explored. Aim of the review This systematic review aimed to critically appraise, synthesise, and present the available evidence on pharmacists’ input to the screening, prevention and management of metabolic syndrome. Method The final protocol was based on the “Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P)”. Studies published in English from January 2008 to March 2020 reporting any pharmacist activities in the screening, prevention or management of metabolic syndrome were included. Databases searched were Medline, Cumulative Index to Nursing and Allied Health Literature, International Pharmaceutical Abstracts, Cochrane and Google Scholar. Studies were assessed for quality by two researchers, data extracted and findings synthesised using a narrative approach. Results Of the 39,430 titles reviewed, ten studies were included (four were randomised controlled trials). Most studies focused on pharmacist input to metabolic syndrome screening and management. Screening largely involved communicating metabolic parameters to physicians. Management of metabolic syndrome described pharmacists collaborating with members of the multidisciplinary team. A positive impact was reported in all studies, including achieving metabolic syndrome parameter goals, reverting to a non-metabolic syndrome status and, improved medication adherence. The populations studied were paediatrics with risk factors, adults with comorbidities and psychiatric patients. Integration of the pharmacist within the multidisciplinary team, an easy referral process and accessibility of service were potential facilitators. Inadequate funding was the key barrier. Conclusion The studies describing pharmacist input in metabolic syndrome provide limited evidence of positive outcomes from screening and management as part of collaborative practice. Further work is required to provide more robust evidence of effectiveness and cost-effectiveness while considering key barriers.
Impacts on Practice
There is a lack of evidence on the role for the pharmacist in metabolic syndrome (MetS), the viable models of care and the beneficial population.
The review suggests that pharmacists can effectively screen patients for MetS, and participate in the prevention and management amongst most at-risk populations and within different settings to enhance patient care.
Further research is warranted to determine the readiness and acceptance for the pharmacist to intervene in MetS from the pharmacists, physicians and patient’s perspective.
The International Diabetes Federation (IDF) estimates that metabolic syndrome (MetS) affects one-quarter of the world’s population, doubling the risk of coronary heart disease, increasing the risk of mortality secondary to coronary heart disease by three-fold and increasing the risk of developing Type 2 diabetes mellitus (DM) fivefold . MetS is a global concern due to its increasing prevalence, primarily due to obesity . As a result, a number of international organisations including the IDF, the American Heart Association, the National Heart, Lung and Blood Institutes (NHLBI), the World Heart Federation, the International Atherosclerosis Society and the International Association for the Study of Obesity harmonised the criteria for metabolic syndrome (MetS). The health consequences associated with MetS are significant, [2, 3] as are the direct and indirect burdens on the healthcare system and society more generally [4,5,6,7,8].
It is estimated that more than 80% of cardiovascular disease (CVD) complications secondary to MetS can be prevented by optimizing blood pressure and lipid profiles , with the most effective, evidence-based measures being lifestyle interventions usually increased physical activity and adopting a healthier diet [10,11,12,13]. Pharmacological treatment is considered in cases of failure of non-pharmacological interventions in achieving modifiable risk factor reduction [14, 15].
To date, most evidence on health professional input to MetS management has centred on physicians and nurses . While these roles are well-defined, there is less evidence supporting pharmacist involvement in MetS management. There is potential for pharmacists to apply their expert medication knowledge and clinical skills to enhance the care of patients who are at risk of or have established MetS.
The clinical and patient-facing roles of the pharmacist in the management of acute and chronic conditions have developed significantly since the seminal publication by Hepler and Strand . This introduced the concept of pharmaceutical care, which was a paradigm shift from dispensing functions towards more proactive, collaborative roles in eliminating preventable drug-related problems (DRPs) . Several systematic reviews and meta-analyses have provided substantial evidence of the impact of pharmacist’s intervention relating to specific MetS risk factors. Four systematic reviews and a meta-analysis of randomised controlled trials (RCTs) reported the effectiveness of the pharmacists’ interventions in the management of Type 1 and 2 DM, reducing HbA1c levels and improving medication and lifestyle adherence following pharmacist intervention . Further systematic reviews and meta-analyses have provided evidence of reduction in systolic and diastolic blood pressure in hypertension (HTN) [19, 20], weight loss in obesity [21, 22] and reduction in CVD related hospitalization and mortality .
Furthermore, there is evidence of positive impact in other chronic conditions, including asthma and chronic obstructive pulmonary disease (COPD) [24, 25].
Growing evidence has suggested that collaborative multidisciplinary care approach in many disciplines is best practice . This supports achieving the aim of better population health, better patient experience and low per capita cost .
A preliminary search of the Cochrane Library of Systematic Reviews and Meta-analysis and the International Database of the Prospectively Registered Systematic Review in Health and Social Science (PROSPERO) using the terms, ‘pharmacist’ and ‘metabolic syndrome’, yielded no related published or ongoing systematic reviews. A search in Medline using the same terms identified a body of primary literature sufficient for a systematic review to be undertaken.
Aim of the review
The aim of this systematic review was to critically appraise, synthesise, and present the evidence on pharmacists’ input to the screening, prevention and management of MetS. Specific objectives were to determine the types of pharmacist input reported in the studies; determine the impact of the reported input; characterise the populations who could benefit most from the input; and identify the facilitators and barriers to the effective implementation of pharmacist input.
The Institutional Review Board (IRB) of the Medical Research Committee at Hamad Medical Corporation (HMC) in Qatar has confirmed that no ethics approval is required since this is a review.
The systematic review protocol was developed based on the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015 guidance  (Online Appendix A) and registered in the International Prospective Register of Systematic Reviews (PROSPERO) .
Inclusion and exclusion criteria
The standard systematic review PICO (population, intervention, comparator and outcomes) approach was employed .
Type of participants
All studies irrespective of population groups were included in the review.
Type of interventions
All pharmacist activities in the screening, prevention or management of MetS were included.
Type of comparator
All studies were included whether or not there was a control group comparing the impact with or without a pharmacist’s input.
Type of outcome
All studies were assessing the pharmacists’ input in the screening, management and prevention of MetS.
The outcomes were diverse and included the following: comparisons of different models of pharmacist input in MetS, descriptions of the process of development of the models, and the clinical outcomes of such interventions.
Types of studies to be included
All studies were included irrespective of design. The initial search indicated that the first relevant article was published in 2008; hence, all studies published between 2008 and March 2020, in the English language were included.
Grey literature was excluded due to the potentially limited quality and difficulties in searching and retrieval .
Search strategy and data sources
The electronic search strategy was guided by the “Peer Review of Electronic Search Strategies” (PRESS) checklist . An initial search of Medline and Cumulative Index to Nursing and Allied Health Literature (CINAHL) was conducted, using keywords of ‘pharma*’ AND ‘metabolic syndrome’ to identify further keywords and search terms. The search string then applied to Medline, CINAHL, Cochrane, International Pharmaceutical Abstracts (IPA) and Google Scholar was (‘Metabolic syndrome*’ OR ‘syndrome x’ OR ‘Insulin resistance syndrome*’ OR ‘Dysmetabolic syndrome*’ OR “Hypertriglyceridemic waist*’ OR ‘Obesity syndrome*’ OR ‘Metabolic Cardiovascular Syndrome’ OR ‘Reaven Syndrome X’ OR ‘Atherothrombogenic syndrome’) AND ‘Pharm*’.
The reference lists of all identified articles were hand searched to identify any further relevant articles. Attempts were made to contact corresponding authors where data were missing or incomplete.
Quality assessment and data extraction
Eligible studies were assessed for quality using standardised quality assessment tools, the Cochrane bias assessment tool and the National Heart, Lung and Blood Institute (NHLBI) quality assessment tools [33, 34]. Quality assessment using these tools was undertaken independently by two reviewers, with any disagreements resolved by discussion and referral to a third reviewer if necessary. RCTs were deemed of good quality if all criteria were of low bias risk as judged by the assessor, fair if the study had one high bias risk or two uncertain bias criteria, and poor if two or more high or uncertain bias criteria .
A data extraction tool was developed by adapting and customizing the “Data collection form for intervention review—RCTs and non-RCTs” from the Cochrane Collaboration . Information was extracted by two independent reviewers.
Given the lack of homogeneity of study aims, participants and outcome measures, a narrative approach to data synthesis was undertaken, using text and tables aligned to each of the review objectives.
The results of the search process
The initial search yielded 39,430 studies. Screening of the titles excluded 39,363 titles, and abstract screening excluded a further 53. Of the 14 remaining studies, four were excluded on full-text review. Of the ten studies included in the following stages four were RCTs; four were cross-sectional design, one a before-and-after study and one was quality improvement project (Fig. 1).
Quality assessment of all included studies is reported in Tables 1 and 2. The RCTs had low bias for the primary outcome measures (Table 1). The key limitation of the cross-sectional studies was the absence of a rationale for, or calculation of, sample size (Table 2). The overall potential risk of bias of the before-and-after study was assessed to be low. Restricting the assessment to a single time point (measuring the outcome once after the outreach visits) and single hospital ward (the study was held in a psychiatric ward of the hospital) were key study limitations (Table 2).
Most of the studies (n = 7) were conducted in South and North America, with two in Europe and one in the Middle East. A total of 1728 participants were included, with sample size ranging from 17 to 650. The four RCTs evaluated the impact of pharmacist contribution in MetS management versus conventional care. One before-and-after study assessed the impact of a pharmacist outreach visit to implement a MetS screening program in a hospital ward. The four cross-sectional studies mainly assessed the usefulness or the implementation of pharmacist-led Mets screening. The quality improvement project evaluated the patient load before and after expansion, with special focus on the type of pharmacist input. Table 3 describes the study findings in relation to the review objectives.
Review objective 1: Description of pharmacist input
Study settings were community pharmacies [36, 37] ambulatory outpatient clinics (family medicine, community health centres and psychiatric clinics) [38,39,40,41,42], and pharmacist outreach visits to psychiatric patients in a hospital ward setting  and as part of a home healthcare service .
The pharmacist input was described in all the studies with varying levels of detail provided. Pharmacist screening of participants for MetS against validated criteria was described in eight studies [37,38,39,40,41,42,43] with screening results communicated to the relevant physician [41, 42]. In two studies, screening of other CV risk factors, using the Framingham risk assessment tool, was additionally reported [36, 37]. Various approaches to participant recruitment were described: clinic referral-based recruitment in three studies [41, 42, 45], appointment booking following appropriate advertisement in the media and the surrounding clinics , recruiting walk-ins to the community pharmacy  or through pharmacist patient history review . Two studies did not clearly report the recruitment process [39, 40].
All RCTs described the baseline assessment of all patients with regular follow-up of the intervention arm, with both baseline and follow up conducted by the pharmacist [38,39,40, 44]. The pharmacist attended the clinic appointment along with the physician in one study  and documented and communicated a plan to the physician in three studies [39, 40, 44]. In two studies, pharmacists also provided recommendations relating to laboratory testing and the need to prescribe new medications for undiagnosed conditions [38,39,40, 44, 45]. Lifestyle modification recommendations were provided by the pharmacist in five studies [38, 39, 41, 42, 44, 45], with only one of these measuring related outcomes using a nonvalidated questionnaire at three to six months  (Table 3).
Review objective 2: Impact of pharmacist role in MetS
Eight studies aimed to determine the impact of the pharmacist input. In the studies focusing on screening, the percentage of the newly diagnosed participants with MetS was reported, these participants would not have been diagnosed if the pharmacy screening service not been available [37, 41, 42]. These patients were followed-up by referral , or by communicating the relevant clinical parameters to the physician [36, 42]. One study demonstrated an improvement in the quality and quantity of documentation completed by physicians relating to MetS screening . No further patient follows up was reported in one study .
The impact in MetS management in collaboration with the multidisciplinary team (MDT) was measured in four RCTs and one cross-sectional study, with improvement of anthropometric and metabolic parameters being the primary outcome measures [38,39,40, 44]. Additionally, determination of patient medication adherence was conducted in one study . All but one study reported positive impact in terms of; achieving MetS parameter goals, reverting to non-MetS status, improved medication adherence and self-reported improved lifestyle modification. The study conducted in a psychiatric outpatient clinic failed to show significant improvement in metabolic parameters after the 12 months study period .
Review objective 3: The beneficiary population
Adults with comorbidities of MetS elements such as DM, HTN, dyslipidemia and obesity, were included in five studies [37,38,39, 44, 45]. Psychiatric patients receiving antipsychotic medications were targeted in three studies [40, 41, 45], since these medications are associated with significant weight gain . One study included children and adolescents at high-risk of MetS, with a first-degree family history of type 2 DM, obesity or acanthosis nigricans , due to the potential link to underlying insulin resistance [47, 48]. Healthy volunteers were the subjects of one study  (Table 3).
Review objective 4: Facilitators and barriers
None of the studies specifically aimed to determine the facilitators and barriers to pharmacist input. Consequently, data relating to facilitators and barriers were extracted by the reviewers. Throughout all studies, the most commonly identified facilitator was effective communication, documentation and appropriate setting for MDT referrals, in addition to active collaboration with the MDT where each member of the MDT had a defined role (Table 4). Lack of funding for reimbursement of pharmacist time, purchasing consumables and other resources such as IT software was the most common barrier identified to the effective implementation of the pharmacist-led activity. Challenging behaviour of psychiatric patients was reported as a barrier in all studies involving psychiatric patients (Table 4).
This is the first published systematic review focusing specifically on pharmacist input in MetS. This review identified ten studies, four of which were RCTs. The most frequently reported inputs were in screening and in management, with prevention-related activities described in one study. The main population studied was adults with comorbidities putting them at higher risk of developing MetS. Beneficial impacts were described in terms of earlier diagnosis, potentially earlier intervention and improvement in the MetS parameters. Successful integration with the MDT, effective communication and accessibility of the community pharmacies were most likely facilitators towards the implementation with lack of funding the most likely barrier.
This review adhered to best practice in conducting and reporting a systematic review, as described in “Preferred Reporting Items for Systematic Reviews and Meta-Analyses” (PRISMA)  (Online Appendix A). The wide range of patient populations reported in the studies may enhance the generalisability of findings to at-risk populations. The main review limitation was restricting the review to papers published in English, resulting in four studies not being included. While the quality of the studies was generally good, reporting could be enhanced by encouraging the authors to adopt robust reporting criteria such as those recommended by the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) network [50, 51].
This systematic review has identified limited evidence upon which to inform the best practice of pharmacist input to MetS. The evidence base is derived from ten studies, only four of which were RCTs. Of the ten studies, there was marked variation in the aims and the models of care delivered, which significantly limits any potential for data pooling. Indeed, only four studies provided a comprehensive description of pharmacist interventions in terms of defined activities, training, processes, documentation, outcomes to be recorded and follow-ups.
A pharmacist-based intervention around MetS could be argued to be a complex intervention as defined by the UK Medical Research Council (MRC) which defines a ‘complex intervention’ as one with several interacting components, involving different behaviours and variability in outcomes . The MRC complex intervention framework has four stages of development, feasibility/pilot testing, evaluation and implementation. It is worth noting that none of the ten studies in this systematic review included all these stages, with particular deficiencies around the development, feasibility and pilot testing stages. Ideally, the interventions should be developed and informed by evidence base in the literature (e.g. a systematic review), consider the theoretical basis for the intervention (e.g. behaviour change theory) and involve all stakeholders in development. Interventions developed according to this system are more likely to be successful compared to those developed pragmatically [52, 53]. There is also a lack of consideration of the MRC framework in the primary studies included in previous systematic reviews describing pharmacists input to managing Mets elements such DM , HTN , obesity  and cardiovascular risk factors .
Despite the absence of application of the MRC framework, this review has provided some evidence of the benefit of the pharmacist input, particularly in the screening for and management of MetS. There were positive outcomes of earlier diagnosis, referrals to the pertinent physician and reaching the MetS parameter goals.
Obese adults with chronic comorbid conditions and paediatrics with risk factors were identified in this review to be among the beneficiary populations. These findings concur with at-risk populations highlighted by international organizations. Moreover, the American Heart Association (AHA) and NHLBI underpin obesity and prediabetes as the main risk factors to develop MetS, in addition to other risk factors such as a sedentary lifestyle, atherogenic diet and older age . This was further supported by the IDF communication consensus worldwide de-finition of MetS in 2006. Central obesity and insulin resistance were defined as the most potent risk factors to develop MetS, in addition to other risk factors such as; ageing, genetic predisposition, sedentary lifestyle, proinflammatory status and reproductive hormonal alteration . Hence, prioritizing the at-risk population is logical and would be recommended, especially at the initial phase of implementing pharmacist-led activity with limited resource and experience.
Additionally, patients receiving antipsychotic medications were recognized by the American Psychiatric Association (APA) as at-risk population for development of MetS due to the strong association with weight gain, dyslipidemia and hyperglycemia, and emphasized the importance of regular screening and monitoring of MetS . This supports the fact that psychiatric patients were also among the beneficiary populations identified in this review.
The challenges facing the implementation of the pharmacist within the collaborative service involving different specialities, including mental health, are common. While the nature of the conditions and the interventions are varied, the need for effective collaboration remains. The findings of a systematic review of 18 studies reporting the facilitators and barriers to the implementation of collaborative practice in mental health were in line with the findings of the current review. To successfully implement a new collaborative service, Wood and colleagues emphasised the importance of adopting a multidisciplinary approach in mental health, including a pharmacist, maintaining effective communications, applying structured care plans and sustaining active patient’s follow-up. On the other hand, the readiness of the organisations and staff for implementation and lack of knowledgeable, self-confident staff, adequate supervision and resources were the more pronounced barriers reported by Wood et al. .
A meta-synthesis of 29 qualitative studies categorized the influencing factors (facilitators and barriers) of implementing an advanced pharmacist run patient centred service into four categories; the patients’ factors, the interpersonal communication factors, organizational and community factors . Among the most prominent factors enhancing implementation of advanced pharmaceutical services were easy accessibility of the service, sufficient resources for IT programmes, educational materials, service promotion, staff incentives, effective collaboration and communication and a predesigned protocol to define the role of each member of the team. The lack of these factors was barriers to implementation of the services . This is similar to findings in this reported systematic review, for example in our study, organizational factors such as limited resources were also a barrier to implementation of pharmacist input to MetS; the interpersonal communication factors such as effective collaboration and communication with other healthcare providers were considered a facilitator, and specific patient factors including the challenging behaviour of psychiatric patients was a barrier to the practical implementation (Table 4).
The findings of this review are consistent with several published systematic reviews that have suggested that the MDT-pharmacist collaboration is the best model of care and facilitated the pharmacist’s role in screening and management of patients with MetS. Showande et al. confirmed the effectiveness of collaborative pharmacist management of Type 1 and Type 2 DM with 41 RCTs included in a systematic review and meta-analysis . Similarly, in an earlier published systematic review by Altowaijri et al. across different settings (inpatient, outpatients and community pharmacies), pharmacist involvement with the MDT in secondary prevention of cardiovascular diseases was associated with better control of the cardiovascular risk factors and improvement in the clinical outcome .
Of paramount importance, emerging studies have suggested strategies to overcome the barriers to the implementation of collaborative pharmacist service. A meta-synthesis of 29 qualitative studies as well as the collaborative practice agreement issued by the national center for chronic disease prevention and health promotion, both have advocated utilizing evidence-informed practice along with seeking support from a leading champion in the field were suggested to alleviate the organisational and staff reluctance toward the implementation of new collaborative services. A multidisciplinary approach with engaging patients and their families was recommended to increase the readiness of the staff and patients to accept the pharmacist service. Emphasizing the potential long-term healthcare cost reduction secondary to the pharmacist collaboration and having more than one source of funding and cutting unnecessary expenses were suggested to overcome the financial barrier [59, 60].
Implications for the further research phase
This systematic review highlighted the gap in the literature and provided evidence about the more effective model-of-care for the pharmacist to intervene in MetS. Future research is warranted to define the potential patient-centred model of care that should be systematically developed, evaluated, implemented and refined based on the MRC evaluation framework. Additionally, further qualitative research to explore in-depth the patients’ behaviours and health care professionals’ perception of the MDT collaborative practice will inform the development of a successful model of care.
The limited number of studies describing pharmacist input in MetS provides some evidence of positive outcomes from screening and management as part of collaborative practice. Further work is required to provide more robust evidence of effectiveness and cost-effectiveness, while considering key barriers, to enable integration within standard practice.
Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
Alberti K, Eckel R, Grundy S, Zimmet P, Cleeman J, Donato K. Harmonizing the metabolic syndrome. A joint interim statement of the IDF Task Force on Epidemiology and Prevention; NHL and Blood Institute; AHA; WHF; IAS; and IA for the Study of Obesity. Circulation. 2009;120(16):1640–5.
Air EL, Kissela BM. Diabetes, the metabolic syndrome, and ischemic stroke: epidemiology and possible mechanisms. Diabetes Care. 2007;30(12):3131–40.
Alberti KGMM, Zimmet P, Shaw J. Metabolic syndrome—a new worldwide definition. A consensus statement from the international diabetes federation. Diabet Med. 2006;23(5):469–80.
Wen CP, Chan HT, Tsai MK, Cheng TY, Chung WS, Chang YC, et al. Attributable mortality burden of metabolic syndrome: comparison with its individual components. Eur J Cardiovasc Prev Rehabil. 2011;18(4):561–73.
Scholze J, Alegria E, Ferri C, Langham S, Stevens W, Jeffries D, et al. Epidemiological and economic burden of metabolic syndrome and its consequences in patients with hypertension in Germany, Spain and Italy; a prevalence-based model. BMC Public Health. 2010;10(1):529.
Schultz AB, Edington DW. Metabolic syndrome in a workplace: prevalence, co-morbidities, and economic impact. Metab Syndr Relat Disord. 2009;7(5):459–68.
Schultz AB, Edington DW. The association between changes in metabolic syndrome and changes in cost in a workplace population. J Occup Environ Med. 2009;51(7):771–9.
Schultz AB, Edington DW. Analysis of the association between metabolic syndrome and disease in a workplace population over time. Value Health. 2010;13(2):258–64.
Wong ND, Pio JR, Franklin SS, L’Italien GJ, Kamath TV, Williams GR. Preventing coronary events by optimal control of blood pressure and lipids in patients with the metabolic syndrome. Am J Cardiol. 2003;91(12):1421–6.
Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care. 1997;20(4):537–44.
Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344(18):1343–50.
Diehl HA. Coronary risk reduction through intensive community-based lifestyle intervention: the Coronary Health Improvement Project (CHIP) experience. Am J Cardiol. 1998;82(10):83–7.
Armstrong C. AHA and NHLBI review diagnosis and management of the metabolic syndrome. Am Fam Physician. 2006;74(6):1039–47.
Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: AHA/NHLBI scientific statement. Circulation. 2005;112(17):2735–52.
Rask Larsen J, Dima L, Correll CU, Manu P. The pharmacological management of metabolic syndrome. Expert Rev Clin Pharmacol. 2018;11(4):397–410.
Mallory AM, Angosta AD, Kawi J. A patient with metabolic syndrome and the role of the advanced practice registered nurse. Medsurg Nurs. 2014;23(4):245–50.
Hepler CD, Strand LM. Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharm. 1990;47(3):533–43.
Van Eikenhorst L, Taxis K, van Dijk L, de Gier H. Pharmacist-led self-management interventions to improve diabetes outcomes. A systematic literature review and meta-analysis. Front Pharmacol. 2017;8:891.
Cheema E, Sutcliffe P, Singer DR. The impact of interventions by pharmacists in community pharmacies on control of hypertension: a systematic review and meta-analysis of randomized controlled trials. Br J Clin Pharmacol. 2014;78(6):1238–47.
Fleming S, Atherton H, McCartney D, Hodgkinson J, Greenfield S, Hobbs FD, et al.. Self-screening and non-physician screening for hypertension in communities: a systematic review. Am J Hypertens. 2015;28(11):1316–24.
Gordon J, Watson M, Avenell A. A systematic review of weight management interventions in the community pharmacy setting. Proc Nutr Soc. 2010;69:E501.
Omboni S, Caserini M. Effectiveness of pharmacist’s intervention in the management of cardiovascular diseases. Open Heart. 2018;5(1):e000687.
Parajuli DR, Kourbelis C, Franzon J, Newman P, McKinnon RA, Shakib S, et al. Effectiveness of the pharmacist-involved multidisciplinary management of heart failure to improve readmission and mortality rates: systematic review and meta-analysis of randomized controlled trials. Eur Heart J. 2018;39(suppl_1):564.
Mubarak N, Hatah E, Khan TM, Zin CS. A systematic review and meta-analysis of the impact of collaborative practice between community pharmacist and general practitioner on asthma management. J Asthma Allergy. 2019;12:109.
Hesso I, Gebara SN, Kayyali R. Impact of community pharmacists in COPD management: inhalation technique and medication adherence. Respir Med. 2016;118:22–30.
Canada c. Collaborative Care. 2019. https://www.canada.ca/en/health-canada/services/health-care-system/reports-publications/primary-health-care/collaborative-care.html#setting1. Accessed Oct 14, 2019.
Institute for Healthcare Improvement. Triple aim—the best care for the whole population at the lowest cost. 2019. http://www.ihi.org/Engage/Initiatives/TripleAim/Pages/default.aspx. Accessed Oct 9, 2019.
Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al.. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015;2(350):g7647.
AlAdawi RM, Tonna AP, Stewert D, Rayan C, Eledrisi M, Abdelaziz H. The impact of pharmacists’ input on the screening, management and prevention of metabolic syndrome. 2018. http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42018089862. Accessed Aug 2018, 2018.
Schardt C, Adams MB, Owens T, Keitz S, Fontelo P. Utilization of the PICO framework to improve searching PubMed for clinical questions. BMC Med Inform Decis Mak. 2007;7(1):16.
Guides.library.cornell.edu. LibGuides: Gray Literature. 2019. http://guides.library.cornell.edu/graylit. Accessed Jan 25, 2019.
McGowan J, Sampson M, Salzwedel DM, Cogo E, Foerster V, Lefebvre C. PRESS peer review of electronic search strategies: 2015 guideline statement. J Clin Epidemiol. 2016;75:40–6.
Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. Br Med J. 2011;343:d5928.
Nhlbi.nih.gov. Study Quality Assessment Tools | National Heart, Lung, and Blood Institute (NHLBI). 2018; https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools. Accessed 5 Sep. 2018.
Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions. London: Wiley; 2011.
Olenak JL, Calpin M. Establishing a cardiovascular health and wellness program in a community pharmacy: screening for metabolic syndrome. J Am Pharm Assoc. 2010;50(1):32–8.
Via-Sosa MA, Toro C, Travé P, March MA. Screening premorbid metabolic syndrome in community pharmacies: a cross-sectional descriptive study. BMC Public Health. 2014;14(1):487.
Hammad E, Yasein N, Tahaineh L, Albsoul-Younes A. A randomized controlled trial to assess pharmacist–physician collaborative practice in the management of metabolic syndrome in a University Medical Clinic in Jordan. J Manag Care Pharm. 2011;17:295.
Plaster CP, Melo DT, Boldt V, Cassaro KO, Lessa FC, Boëchat GA, et al. Reduction of cardiovascular risk in patients with metabolic syndrome in a community health center after a pharmaceutical care program of pharmacotherapy follow-up. Braz J Pharm Sci. 2012;48(3):435–46.
Schneiderhan ME, Shuster SM, Davey CS. Twelve-month prospective randomized study of pharmacists utilizing point-of-care testing for metabolic syndrome and related conditions in subjects prescribed antipsychotics. Prim Care Companion CNS Disord. 2014. https://doi.org/10.4088/PCC.14m01669.
Schneiderhan ME, Batscha CL, Rosen C. Assessment of a point-of-care metabolic risk screening program in outpatients receiving antipsychotic agents. Pharmacother J Hum Pharmacol Drug Ther. 2009;29(8):975–87.
Benavides S, Kohler LA, Souffrant G. A clinical pharmacist’s role in screening for metabolic syndrome in a rural pediatric ambulatory clinic. J Rural Health. 2011;27(2):184–9.
Kjeldsen LJ, Hansen PS, Kristensen AMF, Christensen A, Sørensen CH, Nielsen B. Outreach visits by clinical pharmacists improve screening for the metabolic syndrome among mentally ill patients. Nord J Psychiatry. 2013;67(4):249–57.
Azevedo MG, Pedrosa RS, Aoqui CM, Martins RR, Nagashima Junior T. Effectiveness of home pharmaceutical interventions in metabolic syndrome: a randomized controlled trial. Braz J Pharm Sci. 2017. https://doi.org/10.1590/s2175-97902017000216089.
Ganzer N, Utter B, DeJongh B, Behrens M, Garcia G, Graham R. Re-implementation of a pharmacist-managed metabolic syndrome clinic in an outpatient mental health clinic setting. Ment Health Clin. 2015;5(1):57–62.
Newcomer JW. Metabolic syndrome and mental illness. Am J Manag Care. 2007;13(7):S170–7.
Rafalson L, Eysaman J, Quattrin T. Screening obese students for acanthosis nigricans and other diabetes risk factors in the urban school-based health center. Clin Pediatr. 2011;50(8):747–52.
Otto DE, Wang X, Tijerina SL, Reyna ME, Farooqi MI, Shelton ML. A comparison of blood pressure, body mass index, and acanthosis nigricans in school-age children. J Sch Nurs. 2010;26(3):223–9.
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–9.
Von Elm E, Altman D, Egger M, Pocock S. G tzsche PC, Vandenbroucke JP: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. PLoS Med. 2007;4(10):e296.
EQUATOR Network. EQUATOR Network, Enhancing the quality and transparency of health research. http://www.equator-network.org/. Accessed July 25 2019.
Craig P, Dieppe P, Macintyre S, Michie S, Nazareth I, Petticrew M. Developing and evaluating complex interventions: the new Medical Research Council guidance. Br Med J. 2008;29(337):a1655.
Murphy SA. An experimental design for the development of adaptive treatment strategies. Stat Med. 2005;24(10):1455–81.
Showande SJ, Akande-Sholabi W, Fakeye TO. Clinical and humanistic outcomes of pharmaceutical care interventions in diabetes mellitus: a systematic review and meta-analysis. West Afr Pharm. 2019;30(1):1–21.
Altowaijri A, Phillips CJ, Fitzsimmons D. A systematic review of the clinical and economic effectiveness of clinical pharmacist intervention in secondary prevention of cardiovascular disease. J Manag Care Pharm. 2013;19(5):408–16.
Reus VI, Fochtmann LJ, Eyler AE, Hilty DM, Horvitz-Lennon M, Jibson MD, et al. The American Psychiatric Association practice guideline on the use of antipsychotics to treat agitation or psychosis in patients with dementia. Am J Psychiatry. 2016;173(5):543–6.
Wood E, Ohlsen S, Ricketts T. What are the barriers and facilitators to implementing collaborative care for depression? A systematic review. J Affect Disord. 2017;214:26–43.
Hossain LN, Fernandez-Llimos F, Luckett T, Moullin JC, Durks D, Franco-Trigo L, et al. Qualitative meta-synthesis of barriers and facilitators that influence the implementation of community pharmacy services: perspectives of patients, nurses and general medical practitioners. Br Med J. Open. 2017;7(9):e015471.
Grazier KL, Smiley ML, Bondalapati KS. Overcoming barriers to integrating behavioral health and primary care services. J Prim Care Community Health. 2016;7(4):242–8.
Centers for Disease Control and Prevention. Collaborative practice agreements and pharmacists’ patient care services: a resource for pharmacists. Atlanta: US Department of Health and Human Services; 2013.
Cipolle RJ, Strand LM, Morley PC. Pharmaceutical care practice: the clinician’s guide. 2004.
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Al AdAwi, R.M., Stewart, D., Ryan, C. et al. A systematic review of pharmacist input to metabolic syndrome screening, management and prevention. Int J Clin Pharm 42, 995–1015 (2020). https://doi.org/10.1007/s11096-020-01084-3
- Metabolic syndrome
- Pharmacist role
- Systematic review