Every year, during the monsoon season, dengue, an infectious disease transmitted by the Aedes aegypti mosquito and caused by the dengue virus, occurs. The frequency and prevalence of dengue fever, as well as deaths from its consequences, have increased dramatically in recent years. Despite the fact that the infection has affected a large number of people worldwide, no specific and efficient drug treatment is known. Researchers are working tirelessly to find a cure, focusing their efforts on developing therapeutic treatments that block or inhibit the activity of specific Dengue virus (DENV) proteins. This review focuses on the phytochemical constituents present in traditionally used natural remedies for the treatment of dengue such as papaya leaf extract, goat milk, kiwi fruit, dragon fruit, and coconut water. Undoubtedly, the contents of this review will motivate researchers to do more novel work in this area which will accelerate the journey towards the exploration of the pharmacological activity of natural compounds.
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References
S. Bhatt, P. W. Gething, O. J. Brady, et al., Nature, 496(7446), 504 – 507 (2013).
J. J. Waggoner, L. Gresh, M. J. Vargas, et al., Clin. Infect. Dis., ciw589 (2016).
O. Horstick, Y. Tozan, A. Wilder-Smith, PLoS Negl. Trop. Dis., 9(4), e0003632 (2015).
World Health Organization. Global strategy for dengue prevention and control 2012 – 2020 (2012).
L. Mousson, C. Dauga, T. Garrigues, et al., Genet. Res., 86(1), 1 – 11 (2005).
L. Lambrechts, T. W. Scott, D. J. Gubler, PLoS Negl. Trop. Dis., 4(5), e646 (2010).
P. Reiter, J. Am. Mosq. Control Assoc., 14(1), 83 – 94 (1998).
A. Wilder-Smith, E. E. Ooi, O. Horstick, B. Wills, Lancet, 393(10169), 350 – 363 (2019).
C. P. Simmons, J. J. Farrar, N. van Vinh Chau, B. Wills, N. Engl. J. Med., 366(15), 1423 – 1432 (2012).
B. P. Teh N. B. Ahmad, S. Mohamad, et al., Nutrients, 14, 1584 (2022).
J. Whitehorn, J. Farrar, Br. Med. Bull., 95(1), 161 – 173 (2010).
World Health Organization, Special Programme for Research, Training in Tropical Diseases, World Health Organization. Department of Control of Neglected Tropical Diseases, World Health Organization. Epidemic, & Pandemic Alert. Dengue: guidelines for diagnosis, treatment, prevention and control. World Health Organization, (2009).
N. Gupta, S. Srivastava, A. Jain, U. C. Chaturvedi, Indian J. Med. Res., 136(3), 373 (2012).
S. Ingule, C. Babar, Curr. Trends Pharm. Pharm. Chem., 2(2), 1 – 7 (2020).
Y. S. Tian, Y. Zhou, T. Takagi, et al., Chem. Pharm. Bull., 66(3), 191 – 206 (2018).
V. Kakade, G. Singh, D. Dinesh, et al., Have All Fruits in Diet with Curative Properties during Dengue Fever Treatment (2020).
J. K. O’Donnell, J. Halpin, C. L. Mattson, et al., Morb. Mortal. Wkly. Rep., 66(43), 1197 (2017).
M. M. Wall, J. Food Compos. Anal., 19(5), 434 – 445 (2006).
V. Zunjar, D. Mammen, B. M. Trivedi, Nat. Prod. Res., 29(22), 2097 – 2099 (2015).
A. Canini, D. Alesiani, G. D’Arcangelo, P. Tagliatesta, J. Food Compos. Anal., 20(7), 584 – 590 (2007).
I. E. Juárez-Rojop, C. A Tovilla-Zárate, D. E. Aguilar-Domínguez, et al., Rev. Bras. Farmacogn., 24, 341 – 347 (2014).
S. P. Singh, S. Kumar, S. V. Mathan, et al., DARU J. Pharm. Sci., 28(2), 735 – 744 (2020).
D. J. Williams, S. Pun, M. Chaliha, et al., J. Food Compos. Anal., 29(1), 82 – 86 (2013).
S. Pandey, C. Walpole, P. N. Shaw, et al., Front. Pharmacol., 9, 1319 (2018).
I. I. Wemambu, D. J. Ajose, C. C. Eni, Acta Sci. Microbiol., 1(7), 6 – 10 (2018).
T. Julianti, M. Oufir, M. Hamburger, Planta Medica, 80(13), 1138 – 1142 (2014).
(a) A. Priyadarshi, B. Ram, Int. J. Pharm. Sci. Res., 9(10), 4071 – 4078 (2018). (b) P. Singh, R. L. Singh, N. Pathak, P. K. Singh, et al., Dietary Supplements and Nutraceuticals, 1(9), 1 – 15 (2022).
G. E. Ukpo, M. A. Owolabi, N. O., Imaga, et al., Trop. J. Pharm. Res., 16(1), 127 – 134 (2017).
U. Fatima, S. Shahid, J. Basic Appl. Sci., 14, 210 – 216 (2018).
M. Hariono, J. Julianus, I. Djunarko, et al., Molecules, 26(22), 6922 (2021).
P. N. Kasture, K. H. Nagabhushan, A. Kumar, J. Assoc. Physicians India, 64(6), 15 – 20 (2016).
K. Zandi, B. T. Teoh, S. S. Sam, et al., Virol. J., 8(1), 1 – 11 (2011).
A. Nugroho, H. Heryani, J. S. Choi, H. J. Park, Asian Pac. J. Trop. Biomed., 7(3), 208 – 213 (2017).
T. Zenebe, N. Ahmed, T. Kabeta, G. Kebede, Acad. J. Nutrition, 3(3), 30 – 39 (2014).
H. Kumar, D. Yadav, N. Kumar, et al., Ind. J. Dairy Sci., 69, 513 – 518 (2016).
(a) P. Rani, V. R. Yenuganti, S. Shandilya, et al., Trends Food Sci. Technol., 65, 94 – 102 (2017). (b) F. Ahmed, M. Tamma, U. Pathigadapa, et al., Mol. Pharmaceut., 19(3), 763 – 774 (2022).
(a) V. R. Yenuganti, S. Afroz, R. A. Khan, et al., J. Nanobiotechnology, 20(1), 1 – 15 (2022). (b) L. Vila, K. Beyer, K. M. Järvinen, et al., Clin. & Exp. Allergy, 31(10), 1599 – 1606 (2001).
(a) S. Singh, G. Kaur, R. P. S. Brar, G. S. Preet, Pharma Innovation, 10, 536 – 540 (2021). (b) L. Zhang, X. R. Liu, J. Z. Liu, et al., Biol. Trace Element Res., 183, 254 – 260 (2018).
K. S. Sonu, H. N. Basavaprabhu, Int. J. Chem. Stud., 8, 1013 – 1019 (2020).
G. Mahendru, P. K. Sharma, V. K. Garg, et al., J. Pharm. Biomed. Sci. (JPBMS), 8(08) (2011).
S. Tyagi, A. H. Nanher, S. Sahay, et al., Rashtriya Krishi, 10(2), 98 – 100 (2015).
A. R. Ferguson, L. R. Ferguson, Are kiwifruit really good for you, In: V Int. Symp.on Kiwifruit 610 (2002), pp. 131 – 138.
I. Guroo, S. A. Wani, S. M. Wani, et al., J. Food Process. & Technol., 8(10), 1 – 6 (2017).
(a) D. P. Richardson, J. Ansell, L. N. Drummond, Eur. J. Nutr., 57(8), 2659 – 2676 (2018). (b) I. Nishiyama, Y. Yamashita, M. Yamanaka, et al., J. Agric. Food Chem., 52(17), 5472 – 5475 (2004).
T. S. Conner, B. D. Fletcher, J. J. Haszard, et al., Nutrients, 12(9), 2898 (2020).
D. C. Hunter, M. A. Skinner, F. M. Wolber, et al., Br. J. Nutr., 108(7), 1235 – 1245 (2012).
N. D. Singh, D. Pandey, T. S. Mishra, et al., J. Rev. Agricult. & Allied Fields, 19, 19 – 24 (2018).
W. Stonehouse, C. S. Gammon, K. L. Beck, et al., Can. J. Physiol. Pharmacol., 91(6), 442 – 447 (2013).
L. Drummond, Adv. Food Nutr. Res., 68, 33 – 57 (2013).
(a) E. Khachatrian, Food Struct. 10 Feb (2022) https://foodstruct.com/food/kiwifruit. (b) S. Mishra, H. Edwards, D. Hedderley, et al., Nutrients, 9(11), 1195 (2017).
H. Chawla, M. Parle, M. Yadav, Int. J. Exp. Pharm., 6, 20 – 25 (2016).
(a) M. A. Skinner, J. M. Loh, D. C. Hunter, J. Zhang, Proc. Nutr. Soc., 70(2), 276 – 280 (2011). (b) Q. Shu, U. Mendis De Silva, S. Chen, et al., Food Agric. Immunol., 19(2), 149 – 161 (2008). (c) D. C. Hunter, M. Denis, N. A. Parlane, et al., Nutr. Res., 28(4), 251 – 257 (2008).
C. O. Perera, I. C. Hallett, T. T. Nguyen, J. C. Charles, J. Food Sci., 55(4), 1066 – 1069 (1990).
Q. Hua, C. Chen, N. T. Zur, et al., Plant Physiol. Biochem., 126, 117 – 125 (2018).
A. Yekkaladev, K. R. Chaitanya, Sys. Rev. Pharm., 13(8), 775 – 781 (2022).
X. Bai, T. Zhou, T. Lai, H. Zhang, J. Sci. Ind. Res.(India), 77, 419 – 424 (2018).
A. R. Nur ‘Aliaa, M. K. Siti Mazlina, F. S. Taip, J. Food Process Eng., 34(5), 1523 – 1534 (2011).
H. Song, Q. Chu, F. Yan, et al., J. Gastroenterol. Hepatol., 31(8), 1462 – 1469 (2016).
D. H. Suh, S. Lee, D. Y. Heo, et al., J. Agric. Food Chem., 62(34), 8764 – 8771 (2014).
(a) Y. J. Chang, Y. Pong, S. S. Hassan, W. S. Choo, Access Microbiol., 2, e000073 (2020). (b) G. C. Tenore, E. Novellino, A. J. Basile, Funct. Foods, 4(1), 129 – 136 (2012).
(a) T. L. Le, N. Huynh, P. Quintela-Alonso, Czech J. Food Sci., 39(2), 71 – 94 (2021). (b) S. Wichienchot, M. Jatupornpipat, R. A. Rastall, Food Chem., 120(3), 850 – 857 (2010). (c) A. A. Ariffin, J. Bakar, C. P. Tan, et al., Food Chem., 114(2), 561 – 564 (2009). (d) M. Arivalagan, G. Karunakaran, T. K. Roy, et al., Food Chem., 353, 129426 (2021).
(a) K. Sudha, D. Baskaran, B. Dhanalakshmi, Int. J. Appl., Phys. & Bio-Chem. Res., 7, 7 – 12 (2017). (b) N. P. Minh, N. P. T. Nhan, D. T. Tha, et al., J. Pharm. Sci. Res., 11(3), 1040 – 1043 (2019).
N. A. Al-Mekhlafi, A. Mediani, N. H. Ismail, et al., Microchem. J., 160, 105687 (2021).
(a) M. Naik, S. CK, A. Rawson, Food Rev. Int., 38(6), 1215 – 1236 (2022). (b) Asian and Pacific Coconut Community (APCC). International Codes and Standard for Aqueous Coconut Products, 2nd draft. Standards Task Force, Asian and Pacific Coconut Community, Jakarta, Indonesia (1994).
(a) C. C. Seow, C. N. Gwee, Int. J. Food Sci. Technol., 32(3), 189 – 201 (1997). (b) J. W. Yong, L. Ge, Y. F. Ng, S. N. Tan, Molecules, 14(12), 5144 – 5164 (2009).
P. Rethinam, T. B. Nanda Kumar, Indian Coconut Journal-Cochin, 32(1), 2 – 22 (2001).
H. S. Goldsmith, Brit. J. Surgery, 49, 421 – 422 (1962).
L. Prakash, NutraCos., 7, 6 – 9 (2008).
(a) M. DebMandal, S. Mandal, Asian Pac. J. Trop. Med., 4(3), 241 – 247 (2011). (b) X. Shen, W. Chen, Y. Zheng, et al., Ind. Crops Prod., 96, 110 – 119 (2017).
(a) M. N. Shubhashree, G. Venkateshwarlu, S. H. Doddamani, Res. J. Pharmacogn. & Phytochem., 6(4), 195 (2014). (b) N. R. Sucupira, E. G. Alves Filho, L. M. A. Silva, et al., Food Chem., 216, 217 – 224 (2017).
(a) M. Kumar, S. S. Saini, P. K. Agrawal, et al., J. Food Compos. Anal., 96, 103738 (2021). (b) A. Prades, M. Dornier, N. Diop, J. P. Pain, Fruits, 67(2), 87 – 107 (2012). (c) P. Anurag, T. Rajamohan, Plant Foods Hum. Nutr., 58(3), 1 – 12 (2003).
(a) A. P. Dabesor, A. M. Asowata-Ayodele, P. Umoiette, Am. J. Plant Biol., 2(2), 73 – 76 (2017). (c) S. V. G. Nair, T. Rajamohan, Food Sci. Nutr., 2014, (2014). (b) L. Ge, J. W. H. Yong, S. N. Tan, et al., J. Chromatogr. A, 1048(1), 119 – 126 (2004). (c) V. G. Sandhya, T. Rajamohan, Food Chem. Toxicol., 46(12), 3586 – 3592 (2008).
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Baranwal, J., Singh, S., Kushwaha, S. et al. Utilization of Phytochemicals as Nutraceutical in the Prophylaxis of Dengue. Pharm Chem J 57, 1986–1993 (2024). https://doi.org/10.1007/s11094-024-03105-1
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DOI: https://doi.org/10.1007/s11094-024-03105-1