Skip to main content
SpringerLink
Log in

Chloroacetates of Substituted 1H-Indol-5-,6-,7-Ylamines and Their Antimicrobial Activity

  • SEARCH FOR NEW DRUGS
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Water-soluble 1H-indol-5-, 6-, 7-ylammonium chloroacetates were obtained from the reaction of substituted 1H-indol-5-, 6-, 7-ylamines with chloroacetic acid; identified based on PMR, UV, and mass spectra; and screened in the laboratory for antimicrobial activity. All the tested compounds could suppress the growth of microorganism test strains at various minimum inhibitory concentrations (MICs). The MIC values were observed to depend on the nature and pattern of substitution on the indole system.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S. A. Yamashkin, I. S. Stepanenko, and N. V. Zhukova, Natural and Synthetic Biologically Active Compounds [in Russian], RITs MGPI, Saransk (2020).

  2. I. S. Stepanenko, S. A. Yamashkin, Y. A. Kostina, et al., Bull. Russ. State Med. Univ., 2, 57 – 64 (2019).

    Article  Google Scholar 

  3. I. S. Stepanenko, S. A. Yamashkin, A. I. Kot’kin, and M. A. Yurovskaya, Vestn. Mosk. Univ., Ser. 2: Khim, 60(5), 313 – 317 (2019); Moscow Univ. Chem. Bull., 74(5), 236 – 240 (2019).

  4. I. S. Stepanenko, S. A. Yamashkin, and M. A. Yurovskaya, Vestn. Mosk. Univ., Ser. 2: Khim., 62(1), 37 – 43 (2021); Moscow Univ. Chem. Bull., 75(1), 382 – 388 (2020).

  5. E. A. Alyamkina, N. V. Zhukova, G. A. Solodovnikova, and S. A. Yamashkin, Synthesis of Indole Systems [in Russian], Mordov. Gos. Ped. Inst., Saransk (2010).

  6. MUK 4.2.1890 – 04. Methodical Instructions, Klin. Mikrobiol. Antimikrobn. Khimioter., 6, No. 4 (2004).

  7. A. N. Mironov (ed.), Handbook for Preclinical Drug Studies [in Russian], Grif i K, Moscow (2012).

    Google Scholar 

  8. R. S. Kozlov,M. V. Sukhorukova, M. V. Eidel’shtein, et al., Determination of the Sensitivity of Microorganisms to Antimicrobial Drugs: Clinical Recommendations [in Russian], Smolensk (2018).

  9. E. N. Padeiskaya, Infekts. Antimikrobn. Ter., 5, 150 – 155 (2001).

    Google Scholar 

  10. T. A. Lang and M. Secic, How to Report Statistics in Medicine, American College of Physicians, Philadelphia (2006).

    Google Scholar 

  11. S. A. Yamashkin, Doctoral Dissertation in Chemical Sciences, Moscow (1998).

  12. R. A. Khmel’nitskii, Khim. Geterotsikl. Soedin., 3, 291 – 309 (1974).

  13. P. B. Terent’ev and F. P. Stankyavichus, Mass Spectrometry of Biologically Active Nitrogenous Bases [in Russian], Mokslas, Vilnius (1987).

  14. P. B. Terent’ev, Mass Spectrometry in Organic Chemistry [in Russian], Vysshaya Shkola, Moscow (1979).

  15. A. T. Lebedev, Mass Spectrometry in Organic Chemistry [in Russian], TEKHNOSFERA, Moscow (2015).

    Google Scholar 

  16. E. S. Il’inykh, Mass Spectrometry in Organic Chemistry [in Russian], Izdatel’skii Tsentr YuUrGU, Chelyabinsk (2016).

  17. E. S. Vasil’ev, Khim. Bezop., 3, 78 – 88 (2019).

  18. A. A. Maseikina, I. S. Stepanenko, S. A. Yamashkin, and E. D. Slastnikov, Infekts. Immun., 11, No. 4, 663 – 670 (2021).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Evseviev Mordovian State Pedagogical University, 11a Studencheskaya St., Saransk, 430007, Russia

    S. A. Yamashkin

  2. Volgograd State Medical University, 1 Pavshikh Bortsov Sq., Volgograd, 400131, Russia

    I. S. Stepanenko

  3. Ogarev National Research Mordovian State University, 68 Bol’shevistskaya St., Saransk, 430005, Russia

    A. I. Kiryutina & T. N. Platkova

Authors
  1. S. A. Yamashkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. S. Stepanenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. I. Kiryutina
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. N. Platkova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. A. Yamashkin.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 10, pp. 16 – 21, October, 2023.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yamashkin, S.A., Stepanenko, I.S., Kiryutina, A.I. et al. Chloroacetates of Substituted 1H-Indol-5-,6-,7-Ylamines and Their Antimicrobial Activity. Pharm Chem J 57, 1546–1551 (2024). https://doi.org/10.1007/s11094-024-03047-8

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-024-03047-8

Keywords

Search

Navigation