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An Innovative Stress-Protective and Detoxification Substance for Reducing the Central Nervous System Effects of Alcohol Intoxication

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Pharmaceutical Chemistry Journal Aims and scope

The search for new drugs to reduce the toxic effects of alcohol on the body is based on the creation of various pharmaceutical agents that affect the toxicokinetics and/or toxicodynamics of ethanol. A differentiated approach is needed in the pharmacotherapy of alcoholism due to the different clinical typologies of the condition. Compared with synthetic drugs, herbal remedies have multiple types of activity, which complement their efficacy. Research and development of technology for the manufacture of new drugs based on the hairy agrimony (Agrimonia pilosa) are promising. Experimental studies in which white outbred mice were tested in an open field showed that a hairy agrimony extract reduced orientational-exploratory behavioral activity and contributed to adaptation of the animals to stress. Mice treated with agrimony extract showed a reduction in sensitivity to administration of ethanol: the latent period of falling asleep was reduced by a factor of 1.6 and the duration of sleep decreased by a factor of 3 compared with the group of mice given starch paste. Rats treated with agrimony extract at doses of 100 and 150 mg/kg showed reductions in the duration of ethanol-induced sleep by factors of 1.8 – 2.4 as compared with animals treated with St. John’s wort extract, indicating that the extract had a detoxifying effect. Hairy agrimony extract significantly reduced grooming in all groups of animals, this being associated with its anti-anxiety effect and of great importance in terms of reducing the development of delirium in acute alcohol intoxication.

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Authors and Affiliations

  1. Science Research Institute of Mental Health, Tomsk National Research Medical Center, Russian Academy of Sciences, 4 Aleutskaya Street, 634014, Tomsk, Russia

    T. V. Shushpanova, T. P. Novozheeva, N. A. Bokhan & N. P. Garganeeva

  2. Siberian State Medical University, 2 Moscow Tract, 634050, Tomsk, Russia

    N. A. Bokhan, L. N. Novitskaya, M. I. Smagina, A. V. Matveenko, M. V. Meleshko, N.É. Kolomiets, N. P. Garganeeva & A. S. Pod”yablonskii

  3. E. D. Goldberg Science Research Institute of Regenerative Medicine and Pharmacology, Tomsk National Research Medical Center, Russian Academy of Sciences, 3 Lenin Prospekt, 634028, Tomsk, Russia

    V. V. Udut, S. M. Safronov & R. C. Boev

  4. Science Research Institute of Basic Clinical Immunology, 14 Yadrintsevskaya Street, 630091, Novosibirsk, Russia

    E. V. Markova

  5. Tomsk Polytechnical University, 30 Lenin Prospekt, 634050, Tomsk, Russia

    E. M. Knyazeva

Authors
  1. T. V. Shushpanova
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  2. T. P. Novozheeva
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  3. N. A. Bokhan
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  4. L. N. Novitskaya
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  6. M. I. Smagina
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  7. A. V. Matveenko
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  8. M. V. Meleshko
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  9. N.É. Kolomiets
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  10. N. P. Garganeeva
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  11. A. S. Pod”yablonskii
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  12. S. M. Safronov
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  13. R. C. Boev
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  14. E. V. Markova
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  15. E. M. Knyazeva
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Corresponding author

Correspondence to T. V. Shushpanova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 7, pp. 24 – 31, July, 2023.

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Shushpanova, T.V., Novozheeva, T.P., Bokhan, N.A. et al. An Innovative Stress-Protective and Detoxification Substance for Reducing the Central Nervous System Effects of Alcohol Intoxication. Pharm Chem J 57, 1035–1042 (2023). https://doi.org/10.1007/s11094-023-02981-3

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