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Assessment of the Influences of Filipendula ulmaria Extracts Prepared by Two Methods on the Efficacy of Cytostatic Therapy

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Pharmaceutical Chemistry Journal Aims and scope

Extracts from the above-ground part of the elm-leaved meadowsweet Filipendula ulmaria (L.) Maxim. in 70% ethanol were prepared by extraction using heat (FUh) and countercurrent extraction (FU). Comparative analysis of the actions of these extracts in experiments on C57Bl/6 mice with Lewis lung carcinoma (LLC) indicated that FUh had greater efficacy when used in complex therapy with cyclophosphamide (CPX). FUh (25, 50 and 100 mg/kg) in combination with CPX increased the antitumor effect of CPX against primary tumors. No significant changes were found in the development of the metastatic process in mice given CPX and 50 and 100 mg/kg FUh; FUh at a lower dose (25 mg/kg) weakened the antimetastatic activity of CPX. FU at a dose of 25 mg/kg increased the efficacy of CPX against primary tumors, while use of FU at doses of 50 and 100 mg/kg did not influence the antitumor effect of CPX. In C57Bl/6 mice with lung cancer-67, all FUh doses studied (50, 100, and 200 mg/kg) increased the antimetastatic effect of CPX.

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Authors and Affiliations

  1. E. D. Gol’dberg Science Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Medical Sciences, 3 Lenin Prospekt, 634028, Tomsk, Russia

    E. N. Amosova, I. V. Shilova, E. A. Kiseleva & E. P. Zueva

  2. I. M. Sechenov First Moscow State Medical University, Russian Ministry of Health (Sechenov University), Building 2, 8 Trubetskaya Street, 119991, Moscow, Russia

    F. P. Vetshev

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  1. E. N. Amosova
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Correspondence to I. V. Shilova.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 7, pp. 18 – 23, July, 2023.

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Amosova, E.N., Shilova, I.V., Kiseleva, E.A. et al. Assessment of the Influences of Filipendula ulmaria Extracts Prepared by Two Methods on the Efficacy of Cytostatic Therapy. Pharm Chem J 57, 1029–1034 (2023). https://doi.org/10.1007/s11094-023-02980-4

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