Skip to main content
SpringerLink
Log in

Comparative Evaluation of the Pharmacological Activity of Fatty Aromatic Amides and Amines with a Framework Moiety and Their Non-Covalent Complexes

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Pharmacological studies of the new fatty-aromatic amides, structural analogs of chlorobenzoylaminoadamantane (chlodantane), and non-covalent water-soluble complexes of chlodantane, adamantylbromophenylamine (bromantane) and ADC-918 were carried out. It was shown that complexation neutralized the actoprotective properties of the last three substances. The resulting complexes of arabinogalactan were inclusion compounds where the adaptogen molecule played the role of a guest; the arabinogalactan molecule, a host. Salt-like coordination complexes formed with glycyrrhizic acid. The new derivatives belonged to the third class of moderately toxic compounds. N-[(1R, 2RS)-Camphan-2-yl]-4-chlorobenzamide turned out to be the most promising compound in terms of the pharmacological profile and increased physical performance in the treadmill test by 23.22 – 25.20% 14 d after administration of the studied agent to mice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
Fig. 5.
Fig. 6.

Similar content being viewed by others

References

  1. RU Pat. 1,646,256 (1996); Ref. Zh. Khim., 9O 195P (1997).

    Google Scholar 

  2. S. N. Tandura, V. V. Zarubaev, P. M. Anfimov, and O. I. Kiselev, Antibiot. Khimioter., 58(1 – 2), 36 – 48 (2013).

    CAS  PubMed  Google Scholar 

  3. I. A. Novakov, M. B. Navrotskii, A. S. Mkrtchyan, et al., Zh. Org. Khim., 55(11), 1781 – 1788 (2019).

    Article  Google Scholar 

  4. I. A. Novakov, R. V. Brunilin, G. M. Butov, et al., Zh. Obshch. Khim., 89(3), 366 – 371 (2019).

    Article  Google Scholar 

  5. I. S. Morozov, N. V. Klimova, and L. N. Lavrova, Khim.-farm. Zh., 32(1), 1 – 4 (1998).

    Google Scholar 

  6. S. A. Kutsenko, Principles of Toxicology [in Russian], Foliant, St. Petersburg (2004).

  7. I. V. Sanotskii and I. P. Ulanova, Hazard Criteria in Hygiene and Toxicology for Risk Evaluation of Chemical Compounds [in Russian], Meditsina, Moscow (1975).

    Google Scholar 

  8. T. A. Voronina, I. G. Kapitsa, and E. A. Ivanova, Zh. Nevrol. Psikhiatr. im. S. S. Korsakova, 117(4), 71 – 74 (2017).

    Article  Google Scholar 

  9. A. N. Mironov (ed.), Handbook for Preclinical Drug Studies. Part 1 [in Russian], Grif i K, Moscow (2012).

Download references

Acknowledgments

The research was supported by Russian Science Foundation Grant No. 22-13-20062 (https://rscf.ru/project/22-13-20062/) and a grant of the Volgograd Region Administration under Contract No. 2 of June 10, 2022.

Author information

Authors and Affiliations

  1. Volgograd State Technical University, 28 Prosp. im. Lenina, Volgograd, 400005, Russia

    A. A. Vernigora, R. V. Brunilin, O. V. Vostrikova, I. A. Kirillov, M. B. Nawrozkij & I. A. Novakov

  2. Institute of Solid State Chemistry and Mechanochemistry, 18 Kutatelidze St., Novosibirsk, 630128, Russia

    A. V. Dushkin & E. S. Meteleva

  3. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 9 Prosp. Akad. Lavrent?eva, Novosibirsk, 630090, Russia

    A. A. Kotlyarova, E. A. Morozova & T. G. Tolstikova

  4. Sirius University of Science and Technology, Krasnodar Krai, 354340, Russia

    M. B. Nawrozkij

Authors
  1. A. A. Vernigora
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. V. Brunilin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. V. Vostrikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. V. Dushkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. I. A. Kirillov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. A. Kotlyarova
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. E. S. Meteleva
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. E. A. Morozova
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. M. B. Nawrozkij
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. T. G. Tolstikova
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. I. A. Novakov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. A. Vernigora.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 4, pp. 27 – 37, April, 2023.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vernigora, A.A., Brunilin, R.V., Vostrikova, O.V. et al. Comparative Evaluation of the Pharmacological Activity of Fatty Aromatic Amides and Amines with a Framework Moiety and Their Non-Covalent Complexes. Pharm Chem J 57, 523–534 (2023). https://doi.org/10.1007/s11094-023-02915-z

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-023-02915-z

Keywords

Search

Navigation