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Pharmacological Strategies to Overcome Tumor Resistance to Anticancer Hormonal, Targeted, and Immunotherapy

  • MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
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Pharmaceutical Chemistry Journal Aims and scope

Possible molecular mechanisms of developing tumor drug resistance to anticancer hormonal, targeted, and immunotherapy that are associated with the modification of target molecules and variability of the tumor cell metabolism are considered. Data on the involvement of matrix metalloproteinases, epithelial-mesenchymal transition factors, signaling pathways PI3K/AKT, WNT, RAS, HER2, p53, TGF-â, and apoptosis factors are presented. The influence of the tumor mutation burden and the tumor microenvironment on the development of tumor resistance to targeted drugs and immunotherapy is discussed. New pharmacological strategies to correct drug resistance appear due to continuously updated data of anticancer clinical studies on the use of immunomodulators, monoclonal antibodies, and inhibitors of cyclin-dependent kinases. Structural formulas of modulators of tumor drug resistance to hormone, targeted, and immunotherapy and the main mechanisms of their chemosensitizing activity are presented.

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Authors and Affiliations

  1. Pirogov Russian National Research Medical University, 1 Ostrovityanova St., Moscow, 117997, Russia

    T. A. Fedotcheva & N. L. Shimanovsky

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  1. T. A. Fedotcheva
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  2. N. L. Shimanovsky
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Correspondence to T. A. Fedotcheva.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 57, No. 2, pp. 3 – 11, February, 2023.

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Fedotcheva, T.A., Shimanovsky, N.L. Pharmacological Strategies to Overcome Tumor Resistance to Anticancer Hormonal, Targeted, and Immunotherapy. Pharm Chem J 57, 171–179 (2023). https://doi.org/10.1007/s11094-023-02864-7

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  • DOI: https://doi.org/10.1007/s11094-023-02864-7

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