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New Potentiometric Sensor for Determination of Metformin

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Pharmaceutical Chemistry Journal Aims and scope

A potentiometric metformin-sensitive detector with a plasticized polyvinyl chloride membrane has been developed. The sensor contains an ion associate of metformin with bromophenol blue dye. The response is linear within the range of metformin ion concentrations 1 × 10–-4–1 × 10–-1 M. The slope of the electrode function is characteristic of a singly charged cation. The limit of detection is 8 × 10–-5 M. The sensor can be used for detecting and determining metformin in medicines (RSD = 0.59 – 2.52%).

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Authors and Affiliations

  1. Lesya Ukrainka Volyn National University, Lutsk, 43025, Ukraine

    Zh. Kormosh, S. Golub, O. Yurchenko, T. Savchuk, S. Korolchuk & S. Suprunovich

  2. Volya Medical Institute, Lesya Ukrainka Volyn National University, Lutsk, 43024, Ukraine

    N. Kormosh

  3. Lvivska Politechnika National University, Lviv, 79000, Ukraine

    Yu. Pachenko

  4. Kivertsi Medical Applied College of the Volyn Regional Council, Kiverts, Ukraine

    S. Borkova

Authors
  1. Zh. Kormosh
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  2. N. Kormosh
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  3. S. Golub
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  4. Yu. Pachenko
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  5. O. Yurchenko
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  6. T. Savchuk
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  7. S. Korolchuk
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  8. S. Borkova
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  9. S. Suprunovich
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Corresponding author

Correspondence to Zh. Kormosh.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 8, pp. 59 – 62, August, 2022.

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Kormosh, Z., Kormosh, N., Golub, S. et al. New Potentiometric Sensor for Determination of Metformin. Pharm Chem J 56, 1140–1143 (2022). https://doi.org/10.1007/s11094-022-02765-1

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