A method for obtaining a liposomal form of furanocoumarins from Sosnowsky’s hogweed (SH) is proposed. Furanocoumarins were isolated from SH juice using column chromatography. HPLC analysis found that SH juice contains 5-methoxypsoralen (0.04 g/L) and 8-methoxypsoralen (1.35 g/L). Liposomal vesicles with furanocoumarins were obtained by hydration of a lipid film containing them. The average size of the liposomal vesicles was 219 ± 23 nm. The resulting liposomes produced an antitumor effect when administered intravenously to rats with Walker 256 carcinoma followed by UV irradiation of the tumor node. The antitumor effect of the liposomes consisted of the photosensitizing effect of the furanocoumarins and damage to the tumor by UV radiation. The antitumor action of the furanocoumarins in the liposomal form led to complete remission of the tumor node in two of seven rats observed for 90 d.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 7, pp. 40 – 44, July, 2022.
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Kulikov, O.A., Ageev, V.P., Shlyapkina, V.I. et al. Development of a Liposomal form of Furanocoumarins and Evaluation of its Antitumor Efficacy. Pharm Chem J 56, 979–983 (2022). https://doi.org/10.1007/s11094-022-02736-6
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DOI: https://doi.org/10.1007/s11094-022-02736-6