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Peculiarities of the Application of Mathematical Models Describing Mass-Transfer Processes in Film Coating Technology for a Biconvex Tablet

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Pharmaceutical Chemistry Journal Aims and scope

A review concerning peculiarities of the application of mathematical models describing mass-transfer processes in film coating technology is presented. A formula to calculate the coating film thickness for a biconvex tablet is given. A model based on the Fokker–Planck equation is described. It determines the law of distribution of coated tablets by weight and allows equations for calculating the average weight and dispersion of a coated tablet to be obtained. Therefore, the uniformity of the distribution of the coating material over the tablets can be evaluated. The mass-transfer equations shown in the review make it possible to calculate characteristics such as the product moisture content and the humidity in a coater drum.

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References

  1. Markets and Markets, Markets Research Report (2021).

  2. E. V. Blynskaya, V. B. Markeev, K. V. Alekseev, et al., Khim.-farm. Zh., 55(6), 34 – 46 (2021).

    Google Scholar 

  3. G. Toschkoff and J. G. Khinast, Int. J. Pharm., 457, 407 – 422 (2013).

    Article  CAS  Google Scholar 

  4. V. V. Ayupov, Mathematical Modeling of Technical Systems [in Russian], IPTs Prokrost’, Perm’ (2017).

  5. E. V. Blynskaya, S. V. Tishkov, K. V. Alekseev, and S. V. Minaev, Ross. Bioterapevticheskii Zh., 17(2), 15 – 21 (2018); doi: https://doi.org/10.17650/1726-9784-2018-17-2-15-21.

    Article  Google Scholar 

  6. S. Page, K.-H. Baumann, and P. Kleinebudde, AAPS PharmSciTech, 7(2), E1-E8 (2006).

    Article  Google Scholar 

  7. E. V. Flisyuk and Yu. V. Karboskaya, Film Coatings for Tablets [in Russian], SPKhFA, St. Petersburg (2016).

  8. A. Maroni, L. Zema, G. Loreti, et al., Int. J. Pharm., 457, 362 – 371 (2013).

    Article  CAS  Google Scholar 

  9. Y. Karrout, F. Siepmann, Y. Benzine, et al., Int. J. Pharm., 539, 39 – 49 (2018).

    Article  CAS  Google Scholar 

  10. K. V. Alekseev, E. V. Blynskaya, and S. V. Tishkov, Farm. Delo Tekhnol. Lek., No. 1, 33 – 42 (2020)

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Authors and Affiliations

  1. Zakusov Research Institute of Pharmacology, 8 Baltiiskaya St, Moscow, 125315, Russia

    S. V. Tishkov, D. I. Gavrilov, E. V. Blynskaya, K. V. Alekseev, V. V. Bueva & V. P. Vinogradov

  2. People’s Friendship University of Russia, 6 Miklukho-Maklaya St, Moscow, 117198, Russia

    E. V. Blynskaya

Authors
  1. S. V. Tishkov
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  2. D. I. Gavrilov
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  3. E. V. Blynskaya
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  4. K. V. Alekseev
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  5. V. V. Bueva
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  6. V. P. Vinogradov
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Corresponding author

Correspondence to D. I. Gavrilov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 4, pp. 28 – 33, April, 2022.

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Tishkov, S.V., Gavrilov, D.I., Blynskaya, E.V. et al. Peculiarities of the Application of Mathematical Models Describing Mass-Transfer Processes in Film Coating Technology for a Biconvex Tablet. Pharm Chem J 56, 503–508 (2022). https://doi.org/10.1007/s11094-022-02668-1

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  • DOI: https://doi.org/10.1007/s11094-022-02668-1

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