Approaches to mathematical modeling of heat-transfer processes occurring upon application of film coatings to biconvex tablets are reviewed. Athermodynamic model providing a calculation of the exhaust-air temperature and relative humidity is proposed. The Monte Carlo(Lagrange method of computational fluid dynamics, which consists of tracking the trajectories of drops in physical space, velocity, radii, and temperatures, is considered. Enthalpy equations presented in the review can be used to calculate product and air temperatures in a coater-type drum.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 12, pp. 53 – 59, December, 2022.
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Tishkov, S.V., Gavrilov, D.I., Blynskaya, E.V. et al. Evaluation and Analysis of Mathematical Models of Heat-Transfer Processes Occurring Upon Application of Film Coatings on Biconvex Tablets. Pharm Chem J 56, 1664–1670 (2023). https://doi.org/10.1007/s11094-023-02841-0
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DOI: https://doi.org/10.1007/s11094-023-02841-0