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Piperazine Heterocycles as Potential Anticancer Agents: A Review

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Pharmaceutical Chemistry Journal Aims and scope

Cancer is a rapid, out of control, and proliferation pathology of ordinary cells, which has become one of the most infamous and aggressive health afflictions worldwide. Molecular hybridization is related to a combination of two or more pharmacophores of bioactive frames which generate a single molecular structure with enhanced activity. Previous studies described the piperazine framework as a central structure in numerous synthetic and natural compounds, showing a wide range of biological activities. Here, we review, highlight and discuss a detailed account of the anticancer applications of some important piperazine-containing hybrid heterocycles; we have also included several patents approved for the anticancer activity of piperazine heterocycles.

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References

  1. P. Meena, V. Nemaysh, M. Khatri, et al., Bioorg. Med. Chem., 23(5), 1135 – 1148 (2015).

    Article  CAS  PubMed  Google Scholar 

  2. R. V. Patel, B. Mistry, R. Syed, et al., Eur. J. Pharm. Sci., 88, 166 – 177 (2016).

    Article  CAS  PubMed  Google Scholar 

  3. K. H. Rohde, H. A. Michaels, A. Nefzi, et al., Bioorg. Med. Chem. Lett., 9, 2206 – 2209 (2016).

    Article  Google Scholar 

  4. M. Taha, M. Irshad, S. Imran, et al., Eur. J. Med. Chem., 141, 530 – 537 (2017).

    Article  CAS  PubMed  Google Scholar 

  5. M. Aggarwal, R. Kaur, A. Saha, et al., Antivir. Res., 146, 102 – 111 (2017).

    Article  CAS  PubMed  Google Scholar 

  6. M. Çeçen, J. M. Oh, Z. Özdemir, et al., Molecules, 22, 5371 (2020).

    Article  Google Scholar 

  7. Y. Xu, P. Liang, H. Ur Rashid, et al., Med. Chem. Res., 10, 1618 – 1627 (2019).

    Article  Google Scholar 

  8. B. N. Saðlýk, O. Cebeci, U. Acar Çevik, et al., Molecules, 18, 4342 – 4347 (2020).

    Google Scholar 

  9. G. Y. Zhang, Z. Zhang, K. Li, et al., Bioorg. Chem., 105, 104398 (2020).

    Article  CAS  PubMed  Google Scholar 

  10. Y. Chu, B. R. S. Reddy, V. P. R. Gajulapalli, et al., Bioorg. Med. Chem. Let., 24, 127613 (2020).

    Article  Google Scholar 

  11. W. Li, S. Y. Chen, W. N. Hu, et al., J. Chem. Res., 9, 536 – 542 (2020).

    Article  Google Scholar 

  12. K. S. Thriveni, B. Padmashali, M. B. Siddesh, et al., Ind. J. Pharm. Sci., 4, 332 – 338 (2014).

    Google Scholar 

  13. S. Radi, Y. Toubi, A. Hakkou, et al., Lett. Drug. Des. Discovery, 9, 853 – 857 (2012).

    Article  CAS  Google Scholar 

  14. D. C. Batista, D. P. B. Silva, I. F. Florentino, et al., Inflammopharmacology, 26, 217 – 226 (2018).

    Article  CAS  PubMed  Google Scholar 

  15. E. E. Gurdal, E. Buclulgan, I. Durmaz, et al., Anticancer Agents Med. Chem., 15, 382 – 389 (2015).

    Article  CAS  PubMed  Google Scholar 

  16. N. Inceler, A. Yilmaz, S. N. Baytas, et al., Med. Chem. Res., 22, 3109 – 3118 (2013).

    Article  CAS  Google Scholar 

  17. A. K. El-Damasy, S. H. Seo, N. C. Cho, et al., Eur. J. Med. Chem., 101, 754 – 768 (2013).

    Article  Google Scholar 

  18. M. Al-Ghorbani, G. S. Pavankumar, P. Naveen, et al., Bioorg. Chem., 65, 110 – 117 (2016).

    Article  CAS  PubMed  Google Scholar 

  19. N. Perin, K. Bobanoviæ, I. Zlatar, Eur. J. Med. Chem., 125, 722 – 735 (2017).

    Article  CAS  PubMed  Google Scholar 

  20. H. H. Lin, W. Y. Wu, S. L. Cao, et al., Bioorg. Med. Chem. Lett., 23 3304 – 3307 (2013).

    Article  CAS  PubMed  Google Scholar 

  21. H. Chen, B. B. Xu, T. Sun, et al., Molecules, 22, 1857 – 1866 (2017).

    Article  PubMed Central  Google Scholar 

  22. M. K. Akkoç, M. Y. YükseL, Ý. Durmaz, et al., Turk. J. Chem., 4, 515 – 525 (2012).

    Google Scholar 

  23. M. S. R. Murty, M. R. Katiki, B. R. Rao, et al., Lett. Drug Des. Discovery, 9, 968 – 981 (2016).

    Article  Google Scholar 

  24. J. R. Jiang, F. Xu, H. G. Wu, et al., J. Chem., 1, 2016 (2016).

    Google Scholar 

  25. L. Boddu, A. K. Pagudala, D. Gandamalla, et al., J. Mol. Struct., 1166, 362 – 368 (2018).

    Article  CAS  Google Scholar 

  26. Z. Mao, X. Zheng, Y. Lina, et al., Bioorg. Med. Chem. Lett., 15, 3421 – 3424 (2016).

    Article  Google Scholar 

  27. M. Tuncbilek, E. B. Guven, T. Onder, et al., J. Med. Chem., 55, 3058 – 3065 (2012).

    Article  CAS  PubMed  Google Scholar 

  28. C. Fytas, G. Zoidis, A. Tsotinis, et al., Eur. J. Med. Chem., 26, 281 – 290 (2015).

    Article  Google Scholar 

  29. M. S. Murty, B. Ramalingeswara Rao, K. R. Ram, et al., Med. Chem. Res., 21, 3161 – 3169 (2012).

    Article  CAS  Google Scholar 

  30. S. L. Cao, Y. Han, C. Z. Yuan, et al., Eur. J. Med. Chem., 64, 401 – 409 (2013).

    Article  CAS  PubMed  Google Scholar 

  31. R. Venkatesh, S. Kasaboina, D. Bidayat, et al., Bioorg. Med. Chem. Lett., 27, 354 – 359 (2017).

    Article  CAS  PubMed  Google Scholar 

  32. L. Yurttaş, S. Demirayak, S. Ilgýn, et al., Bioorg. Med. Chem., 22, 6313 – 6323 (2014).

  33. M. Bu, T. Cao, H. Li, et al., Chem. Med. Chem., 6, 466 – 474 (2017).

    Article  Google Scholar 

  34. H. M. Shallal, W. A. Russu, et al., Eur. J. Med. Chem., 46, 2043 – 2057 (2011).

    Article  CAS  PubMed  Google Scholar 

  35. Y. Zhang, Y. Huang, H. Xiang, et al., Eur. J. Med. Chem., 78, 23 – 34 (2014).

    Article  CAS  PubMed  Google Scholar 

  36. P. F. Geng, C. C. Wang, Z. H. Li, et al., Eur. J. Med. Chem., 143, 1959 – 1967 (2018).

    Article  CAS  PubMed  Google Scholar 

  37. S. B. Ozdemir, Y. U. Cebeci, H. Bayrak, et al., Heterocycl. Commun., 23, 43 – 54 (2017).

    Article  Google Scholar 

  38. W. X. Sun, Y. J. Ji, Y.Wan, et al., Bioorg. Med. Chem. Lett., 27, 4066 – 4074 (2017).

    Article  CAS  PubMed  Google Scholar 

  39. Z. H. Li, T. Q. Zhao, X. Q. Liu, et al., Eur. J. Med. Chem., 1396 – 1405 (2018).

  40. P. Wang, J. Huang, K. Wang, et al., Eur. J. Med. Chem., 122, 546 – 556 (2016).

    Article  CAS  PubMed  Google Scholar 

  41. Y. Zhang, C. R. Yang, X. Tang, et al., Bioorg. Med. Chem. Let., 19, 4666 – 4670 (2016).

    Article  Google Scholar 

  42. R. Aeluri, M. Alla, S. Polepalli, N. Jain, et al., Eur. J. Med. Chem., 100, 18 – 23 (2015).

    Article  CAS  PubMed  Google Scholar 

  43. K. S. Kumar, A. Hanumappa, M. Hegde, et al., Eur. J. Med. Chem., 81, 341 – 349 (2014).

    Article  Google Scholar 

  44. H. N. Nagesh, N. Suresh, G. V. Prakash, et al., Med. Chem. Res., 24, 523 – 532 (2015).

    Article  CAS  Google Scholar 

  45. J. Sun, S. Z. Ren, X. Y. Lu, et al., Bioorg. Med. Chem., 25, 2593 – 2600 (2017).

    Article  CAS  PubMed  Google Scholar 

  46. L. K. Filak, D. S. Kalinowski, T. J. Bauer, et al., Inorg. Chem., 53, 6934 – 6943 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. R. V. Patel, P. K. Patel, P. Kumari, et al., Eur. J. Med. Chem., 53, 41 – 51 (2011).

    Article  Google Scholar 

  48. L. Nagarapu, H. K. Gaikwad, R. Bantu, et al., Eur. J. Med. Chem., 46, 2152 – 2156 (2011).

    Article  CAS  PubMed  Google Scholar 

  49. S. Kumar, N. Kumar, P. Roy, et al., Med. Chem. Res, 22, 4600 – 4609 (2013).

    Article  CAS  Google Scholar 

  50. M. N. Aboul-Enein, A. M. El-Azzouny, F. A. Ragab, et al., Arch. Pharm. Chem. Life Sci., 3, 350 (2017).

    Google Scholar 

  51. C. B. Mishra, R. K. Mongre, S. Kumari, et al., ACS Chem. Biol.,12, 753 – 768 (2017).

    Article  CAS  PubMed  Google Scholar 

  52. M. El-Miligy, H. A. Abd El Razik, M. M. Abu-Serie, et al., Future Med. Chem., 9, 1709 – 1729 (2017).

Download references

CONFLICT OF INTEREST

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Chemistry, Ulla Science and Arts College, Taibah University, Madinah Mnoora, Saudi Arabia

    Mohammed Al-Ghorbani, Moustafa A. Gouda & Osama Alharbi

  2. Department of Chemistry, Education College, University of Thamar, Thamar, Yemen

    Mohammed Al-Ghorbani

  3. Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura, Egypt

    Moustafa A. Gouda

  4. Department of Chemistry, Science and Humanities College, Shaqra University, Shaqra, Saudi Arabia

    Mohammed Baashen

  5. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm AlQura University, Makkah, 21955, Saudi Arabia

    Faisal A. Almalki

  6. Department of Chemistry, The National Institute of Engineering, Mysore, Karnataka, 570008, India

    Lakshmi V. Ranganatha

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  1. Mohammed Al-Ghorbani
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  2. Moustafa A. Gouda
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  3. Mohammed Baashen
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  4. Osama Alharbi
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  5. Faisal A. Almalki
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  6. Lakshmi V. Ranganatha
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Correspondence to Mohammed Al-Ghorbani.

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Al-Ghorbani, M., Gouda, M.A., Baashen, M. et al. Piperazine Heterocycles as Potential Anticancer Agents: A Review. Pharm Chem J 56, 29–37 (2022). https://doi.org/10.1007/s11094-022-02597-z

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  • DOI: https://doi.org/10.1007/s11094-022-02597-z

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