The antioxidant properties of dihydroquercetin (DHQ, taxifolin), its aminomethylated derivative (KH-14), and their inclusion complexes in cyclodextrin were compared. The results indicated that DHQ and KH-14 had comparable antioxidant activities. The antioxidant activities of DHQ and KH-14 were preserved upon formation of the inclusion complexes in cyclodextrin. Taxifolin, KH-14, and the water-soluble inclusion complex of KH-14 in cyclodextrin at a dose of 0.04 mmol/kg exhibited pronounced anti-inflammatory effects on the model of carrageenan-induced paw edema in mice that were equivalent to that of diclofenac at a dose of 0.02 mmol/kg.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 8, pp. 25 – 27, August, 2021.
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Rogovskii, V.S., Matyushin, A.I., Koroteev, A.M. et al. Antioxidant and Anti-Inflammatory Activities of Dihydroquercetin, its Aminomethylated Derivative, and their Inclusion Complexes with Cyclodextrin. Pharm Chem J 55, 778–780 (2021). https://doi.org/10.1007/s11094-021-02493-y
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DOI: https://doi.org/10.1007/s11094-021-02493-y