The synthesis of the dihydroartemisinin ester of 1,1′-ferrocenedicarboxylic acid (III) is described. Results of in vitro studies of its effect on the viability of cell cultures of fibroblasts and tumor cells (K562, HEp-2, HeLa) are presented. The selectivity of III at a concentration of 125 μM was 1.2 times greater for myelogenous leukemia cells (K562) than for fibroblasts, indicating that its antiproliferative activity against tumor cells was selective and that in vivo studies of antitumor compound III were feasible, especially for cases of iron-deficiency anemia.
Similar content being viewed by others
References
M. P. Crespo-Ortiz and M. Q. Wei, J. Biomed. Biotechnol., 2012, 1 – 18 (2012).
Z.Wang,W. Hu, J. L. Zhang, et al., FEBS Open Bio, 2, 103 – 112 (2012).
Q. Wang, S. Wu, X. Zhao, et al., PLOS One, 10(10), e0137331 (2015).
S. Krishna, L. Bustamante, R. K. Haynes, and H. M. Staines, Trends Pharmacol. Sci., 29(10), 520 – 527 (2008).
A. Das, Ann. Med. Health Sci. Res., 5(2), 93 (2015).
C. Reiter, T. Frohlich, M. Zeino, et al., Eur. J. Med. Chem., 97, 164 – 172 (2015).
T. A. Fedotcheva, E. D. Sveshnikova, N. I. Sheina, et al., Pharm. Chem. J., 54, 119 – 125 (2020).
A. N. Filatov and I. G. Andrianova, Khim.-farm. Zh., 4(4), 45 – 48 (1970).
G. N. Yashchenko, A. A. Shashmurina, G. M. Anoshina, et al., Khim.-farm. Zh., 12(10), 68 – 72 (1978).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 6, pp. 8 – 11, June, 2021.
Rights and permissions
About this article
Cite this article
Shaikhina, S.U., Semeikin, A.V., Gudovshchikov, I.A. et al. Synthesis and Cytotoxicity of the Dihydroartemisinin Ester of 1,1′-Ferrocenedicarboxylic Acid. Pharm Chem J 55, 536–539 (2021). https://doi.org/10.1007/s11094-021-02455-4
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11094-021-02455-4