Skip to main content

Advertisement

SpringerLink
Log in

Evaluation of the Effectiveness of Intra-Articular Administration of Dexamethasone Liposomal Form on a Model of Rheumatoid Arthritis in Rats

  • Published:
Pharmaceutical Chemistry Journal Aims and scope

Joint diseases are frequently treated using intra-articular injection forms of drugs based on glucocorticosteroids, many of which have disadvantages that hinder increasing their effectiveness. Liposomal forms of glucocorticosteroids are of particular interest for intra-articular administration in the treatment of arthritis. Liposomes with an average vesicle size of 86 ± 5 nm and a dexamethasone concentration of 2.2 ± 0.007 mg/mL were obtained in the present study. The therapeutic efficacy of the obtained liposomes with dexamethasone was studied in comparison with intra-articular administration of dexamethasone solution at the same dose in a rat rheumatoid arthritis model. The criteria for drug effectiveness were macro- and microscopic signs of arthritis in the ankle joints. The liposomal form turned out to be much more effective in comparison to the solution at equal doses as a medicine for reducing the main pathoanatomical signs of the inflammatory process in joints.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Zhonghua Nei Ke Za Zhi (Chin. J. Integr. Med.), 57, 242 – 250 (2018); https://doi.org/10.3760/cma.j.issn.0578-1426.2018.04.004.

  2. D. Aletaha and J. S. Smolen, J. Am. Med. Assoc., 320, 1360 – 1372 (2018).

    Article  Google Scholar 

  3. T. Chen, B. Zhang, Y. Lin, et al., Pharmacology, 104, 216 – 225 (2019).

    Article  CAS  Google Scholar 

  4. R. Di Paola and S. Cuzzocrea, Autoimmun. Rev., 8, 73 – 75 (2008).

    Article  Google Scholar 

  5. M. Gulati, M. Grover, S. Singh, and M. Singh, Int. J. Pharm., 165(2), 129 – 168 (1998).

    Article  CAS  Google Scholar 

  6. M. Gulati, S. Singh, D. Chopra, et al., Curr. Rheumatol. Rev., 4(1), 63 – 70 (2008).

    Article  CAS  Google Scholar 

  7. F. Lopez-Garcia, J. M. Vazquez-Auton, F. Oil, et al., J. Pharm. Pharmacol., 45(6), 576 – 578 (1993).

    Article  CAS  Google Scholar 

  8. B. Kapoor, S. K. Singh, M. Gulati, et al., Sci. World J., 2014, 1 – 17 (2014).

    Article  Google Scholar 

  9. O. A. Kulikov, N. A. Pyataev, A. V. Zaborovskii, et al., Bull. Exp. Biol. Med., 163(6), 742 – 744 (2017).

    Article  CAS  Google Scholar 

  10. Q. Zhang, W. Peng, S. Wei, et al., Biomed. Pharmacother., 118, 1 – 15 (2019).

    Google Scholar 

  11. C. Su, Y. Chen, Y. Chen, et al., Mol. Med. Rep., 20(5), 4101 – 4110 (2019).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. S. Y. Min, K. S. Park, M. L. Cho, et al., Arthritis Rheum., 54(3), 887 – 898 (2006).

    Article  CAS  Google Scholar 

  13. T. F. He, W. J. Yang, S. H. Zhang, et al., Evidence-Based Complementary Altern. Med., 2011, 1 – 8 (2011).

    Google Scholar 

  14. H. Tang, Y. J. Wu, F. Xiao, et al., Biomed. Pharmacother., 119, 1 – 13 (2019).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. N. P. Ogarev Mordovia State University, 68 Bol’shevistskaya St., Saransk, Mordovia, 430005, Russia

    O. A. Kulikov, V. P. Ageev, V. I. Shlyapkina & N. A. Pyataev

  2. A. I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, 20/1 Delegatskaya St., Moscow, 127473, Russia

    A. V. Zaborowskii, D. V. Yunina, K. G. Gurevich, L. A. Tararina, A. G. Mulyar & D. N. Andreev

Authors
  1. O. A. Kulikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. V. Zaborowskii
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. V. Yunina
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. G. Gurevich
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. A. Tararina
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. V. P. Ageev
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. V. I. Shlyapkina
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. N. A. Pyataev
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A. G. Mulyar
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. D. N. Andreev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. V. Zaborowskii.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 5, pp. 37 – 41, May, 2021.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kulikov, O.A., Zaborowskii, A.V., Yunina, D.V. et al. Evaluation of the Effectiveness of Intra-Articular Administration of Dexamethasone Liposomal Form on a Model of Rheumatoid Arthritis in Rats. Pharm Chem J 55, 494–498 (2021). https://doi.org/10.1007/s11094-021-02447-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11094-021-02447-4

Keywords

Search

Navigation