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Elimination Half-Life of Short Peptide Drugs in Humans Extrapolated From Animal Pharmacokinetic Pharmacokinetic Studies

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Results from an interspecies scaling study of the elimination half-lives of the anxiolytic GB-115 and the antipsychotic dilept in rats, rabbits, and humans are presented. The elimination half-lives of the studied drugs are calculated in real (chronological) and corrected time (pharmacokinetic). Elimination half-lives in animals and volunteers are compared. Rabbits are found to be a better scaling model for GB-115 although a single preference for dilept was not found.

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Authors and Affiliations

  1. V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, 125315, Russia

    A. A. Litvin, R. V. Shevchenko, G. B. Kolyvanov, P. O. Bochkov, S. Yu. Raskin, O. G. Gribakina, V. P. Zherdev, L. G. Kolik & T. A. Gudasheva

  2. I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119991, Russia

    V. V. Smirnov

  3. Maluna-Pharm Joint Stock Company, Moscow, 125315, Russia

    N. Yu. Ivashkina

Authors
  1. A. A. Litvin
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  2. R. V. Shevchenko
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  3. G. B. Kolyvanov
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  4. P. O. Bochkov
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  5. V. V. Smirnov
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  6. S. Yu. Raskin
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  7. O. G. Gribakina
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  8. V. P. Zherdev
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  9. L. G. Kolik
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  10. T. A. Gudasheva
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  11. N. Yu. Ivashkina
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Corresponding author

Correspondence to L. G. Kolik.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 8, pp. 16 – 19, August, 2019.

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Litvin, A.A., Shevchenko, R.V., Kolyvanov, G.B. et al. Elimination Half-Life of Short Peptide Drugs in Humans Extrapolated From Animal Pharmacokinetic Pharmacokinetic Studies. Pharm Chem J 53, 685–688 (2019). https://doi.org/10.1007/s11094-019-02063-3

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  • DOI: https://doi.org/10.1007/s11094-019-02063-3

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