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Development of a Dosage Form of the New Antitumor Antibiotic Olivamide

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

Methods for selective chemical modification of the antitumor antibiotic olivomycin A(OA) were developed at GINA. The compound olivamide with advantages over starting OA was selected from series of OA analogs. The goal of the present work was to develop a dosage form of the antitumor semi-synthetic antibiotic olivamide that guaranteed the stability and high specific activity of olivamide drug substance and was designed for further comprehensive preclinical studies.

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Authors and Affiliations

  1. G. F. Gause Institute of New Antibiotics (GINA), 11/1 Bol’shaya Pirogovskaya St., Moscow, 119021, Russia

    A. N. Tevyashova, E. N. Bychkova, L. G. Dezhenkova & A. E. Shchekotikhin

  2. D. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya Sq., Moscow, 125047, Russia

    A. N. Tevyashova & A. E. Shchekotikhin

Authors
  1. A. N. Tevyashova
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  2. E. N. Bychkova
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  3. L. G. Dezhenkova
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  4. A. E. Shchekotikhin
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Corresponding author

Correspondence to A. N. Tevyashova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 52, No. 11, pp. 42 – 47, November, 2018.

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Tevyashova, A.N., Bychkova, E.N., Dezhenkova, L.G. et al. Development of a Dosage Form of the New Antitumor Antibiotic Olivamide. Pharm Chem J 52, 930–935 (2019). https://doi.org/10.1007/s11094-019-01928-x

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  • DOI: https://doi.org/10.1007/s11094-019-01928-x

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